The Fabrication of Microfluidics, 3D Cell Culture, Organ-on-a-Chip

The design and development of lab-on-a-chip devices enables high-throughput screening of drugs. In this week’s issue of “From Academia”, we share with you the three latest publications focusing on alternative materials for the fabrication of microfluidics or organ-on-a-chip, 3D cell culturing microfluidic devices, and microfluidics using digital light processing. The first article explores the design and development of a cost-effective 3D cell culturing microfluidics device using polydimethylsiloxane (PDMS), allowing high-throughput screening of anti-cancer drugs in 3D tumour spheroids. The second article demonstrates the feasibility of a 3D printed PDMS-based Microfluidic Device utilizing Digital Light Processing (DLP) printing technique. Beyond the use of PDMS materials, the third article reviews the fabrication of organ-on-a-chip and Microphysiological systems using alternative materials other than PDMS.

From Academia” features recent, relevant, close to commercialization academic publications. Subjects include but not limited to healthcare 3D printing, 3D bioprinting, and related emerging technologies.

Email: Rance Tino ( if you want to share relevant academic publications with us.

Characterising a PDMS based 3D cell culturing microfluidic platform for screening chemotherapeutic drug cytotoxic activity

Authored by M. Ibrahim Khot, Mark A. Levenstein, Greg N. de Boer, Gemma Armstrong, Thomas Maisey, Hafdis S. Svavarsdottir, Helen Andrew, Sarah L. Perry, Nikil Kapur & David G. Jayne, Nature Scientific Reports. 28 September 2020 

Fabrication and Functionalization of 3D Printed Polydimethylsiloxane‐Based Microfluidic Devices Obtained through Digital Light Processing

Authored by Gustavo Gonzalez  Annalisa Chiappone  Kurt Dietliker  Candido Fabrizio Pirri  Ignazio Roppolo. Advanced Material Technologies. 29 July 2020

Beyond Polydimethylsiloxane: Alternative Materials for Fabrication of Organ-on-a-Chip Devices and Microphysiological Systems

Authored by Scott B. Campbell, Qinghua Wu, Joshua Yazbeck, Chuan Liu, Sargol Okhovatian, and Milica Radisic. ACS Biomaterials Science & Engineering. 11 August 2020

3D Printing Ceramic Implants

3D Bioprinting Knee, Aneurysm Model, 3D Organization Using Microfluidics

3D Printing Pharmaceuticals and Drug Delivery Devices

3D Bioprinting The Heart & Cardiovascular System

Machine Learning in 3D Printing and Bioprinting, a Collection of Recent Publications

3D Printing for Neurosurgery Training, Vat Photopolymerization, soft robotic microsystem

Open-Source 3D printed Medical Devices and New Sensor for COVID

Other similar articles