The design and development of lab-on-a-chip devices enables high-throughput screening of drugs. In this week’s issue of “From Academia”, we share with you the three latest publications focusing on alternative materials for the fabrication of microfluidics or organ-on-a-chip, 3D cell culturing microfluidic devices, and microfluidics using digital light processing. The first article explores the design and development of a cost-effective 3D cell culturing microfluidics device using polydimethylsiloxane (PDMS), allowing high-throughput screening of anti-cancer drugs in 3D tumour spheroids. The second article demonstrates the feasibility of a 3D printed PDMS-based Microfluidic Device utilizing Digital Light Processing (DLP) printing technique. Beyond the use of PDMS materials, the third article reviews the fabrication of organ-on-a-chip and Microphysiological systems using alternative materials other than PDMS.
“From Academia” features recent, relevant, close to commercialization academic publications. Subjects include but not limited to healthcare 3D printing, 3D bioprinting, and related emerging technologies.
Email: Rance Tino (email@example.com) if you want to share relevant academic publications with us.
Characterising a PDMS based 3D cell culturing microfluidic platform for screening chemotherapeutic drug cytotoxic activity
Authored by M. Ibrahim Khot, Mark A. Levenstein, Greg N. de Boer, Gemma Armstrong, Thomas Maisey, Hafdis S. Svavarsdottir, Helen Andrew, Sarah L. Perry, Nikil Kapur & David G. Jayne, Nature Scientific Reports. 28 September 2020
Fabrication and Functionalization of 3D Printed Polydimethylsiloxane‐Based Microfluidic Devices Obtained through Digital Light Processing
Authored by Gustavo Gonzalez Annalisa Chiappone Kurt Dietliker Candido Fabrizio Pirri Ignazio Roppolo. Advanced Material Technologies. 29 July 2020
Beyond Polydimethylsiloxane: Alternative Materials for Fabrication of Organ-on-a-Chip Devices and Microphysiological Systems
Authored by Scott B. Campbell, Qinghua Wu, Joshua Yazbeck, Chuan Liu, Sargol Okhovatian, and Milica Radisic. ACS Biomaterials Science & Engineering. 11 August 2020