Apr 03, 2021 There has been an uptick in research activities focusing on 3D bioprinting for bone regeneration. In this issue of “From Academia”, we include four recent publications tackling the issue from different angles. The first article focuses on a new 3D printing composite using silicone resing derived larnite/C scaffold to create new regeneration and treatment strategies for bone tumor patients. The second study focuses on a new bio-ink for 3D bioprinting bone, nanoengineered ionic covalent entanglement (NICE) bioink formulation, which not only showed good printability, mechanical properties, biodegradability, but also the ability to induce endochondral differentiation of encapsulated human mesenchymal stem cells (hMSCs) in the absence of an osteoinductive agent on a genetic level. In the third study, researchers developed a new PLA-based composite formulation that could be used to produce bone scaffold and regeneration. In the last article, a new iron-based ink formulation, as well as matching 3D printing, de-binding, and sintering conditions, was developed to create iron scaffolds with a porosity of 67%, pore interconnectivity of 96%, and a strut density of 89% after sintering. The study shows the great potential of extrusion-based 3D printed porous iron to be further developed as a biodegradable bone substituting biomaterial.
“From Academia” features recent, relevant, close to commercialization academic publications. Subjects include but not limited to healthcare 3D printing, 3D bioprinting, and related emerging technologies.
Email: Rance Tino (info@3dheals.com) if you want to share relevant academic publications with us.
Silicone resin derived larnite/C scaffolds via 3D printing for potential tumor therapy and bone regeneration
Authored by Shengyang Fu, Haoran Hu, Jiajie Chen, Yufang Zhu, Shichang Zhao. Chemical Engineering Journal. 15 February 2020
Nanoengineered Osteoinductive Bioink for 3D Bioprinting Bone Tissue
Authored by David Chimene, Logan Miller, Lauren M. Cross, Manish K. Jaiswal, Irtisha Singh, and Akhilesh K. Gaharwar. ACS Applied Materials & Interfaces. 24 February 2020
Biocompatible heterogeneous bone incorporated with polymeric biocomposites for human bone repair by 3D printing technology
Authored by Meiling Wan Shuifeng Liu Da Huang Yang Qu Yang Hu Qisheng Su Wenxu Zheng Xianming Dong Hongwu Zhang Yen Wei Wuyi Zhou. Journal of Applied Polymer Science. 24 November 2020
Extrusion-based 3D printed biodegradable porous iron
Authored by N.E. Putra, M.A. Leeflang, M. Minneboo, P. Taheri, L.E. Fratila-Apachitei, J.M.C. Mol, J. Zhou, A.A. Zadpoor. Acta Biomaterialia. May 2020
Related Articles:
3D Printing In Orthopedics: Implants, Drug Delivery, Bone Regeneration
Bone Grafts: Inducing Bone Regeneration with 3D Printed Porosity
Bio Fabrication Techniques for Bone and Cartilage Tissue Regeneration
3D Bioprinting Bone – One Defect At A Time
An Introduction to Scaffolds for Tissue Engineering of the Bone and Cartilage
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