From Academia: 3D Bioprinting for Bone Regeneration

There has been an uptick in research activities focusing on 3D bioprinting for bone regeneration. In this issue of “From Academia”, we include four recent publications tackling the issue from different angles. The first article focuses on a new 3D printing composite using silicone resing derived larnite/C scaffold to create new regeneration and treatment strategies for bone tumor patients. The second study focuses on a new bio-ink for 3D bioprinting bone, nanoengineered ionic covalent entanglement (NICE) bioink formulation, which not only showed good printability, mechanical properties, biodegradability, but also the ability to induce endochondral differentiation of encapsulated human mesenchymal stem cells (hMSCs) in the absence of an osteoinductive agent on a genetic level. In the third study, researchers developed a new PLA-based composite formulation that could be used to produce bone scaffold and regeneration. In the last article, a new iron-based ink formulation, as well as matching 3D printing, de-binding, and sintering conditions, was developed to create iron scaffolds with a porosity of 67%, pore interconnectivity of 96%, and a strut density of 89% after sintering. The study shows the great potential of extrusion-based 3D printed porous iron to be further developed as a biodegradable bone substituting biomaterial.

From Academia” features recent, relevant, close to commercialization academic publications. Subjects include but not limited to healthcare 3D printing, 3D bioprinting, and related emerging technologies.

Email: Rance Tino ( if you want to share relevant academic publications with us.

Silicone resin derived larnite/C scaffolds via 3D printing for potential tumor therapy and bone regeneration

Authored by Shengyang Fu, Haoran Hu, Jiajie Chen, Yufang Zhu, Shichang Zhao. Chemical Engineering Journal. 15 February 2020

Nanoengineered Osteoinductive Bioink for 3D Bioprinting Bone Tissue

Authored by David Chimene, Logan Miller, Lauren M. Cross, Manish K. Jaiswal, Irtisha Singh, and Akhilesh K. Gaharwar. ACS Applied Materials & Interfaces. 24 February 2020 

Biocompatible heterogeneous bone incorporated with polymeric biocomposites for human bone repair by 3D printing technology

Authored by Meiling Wan  Shuifeng Liu  Da Huang  Yang Qu  Yang Hu  Qisheng Su  Wenxu Zheng  Xianming Dong  Hongwu Zhang  Yen Wei  Wuyi Zhou. Journal of Applied Polymer Science. 24 November 2020

Extrusion-based 3D printed biodegradable porous iron

Authored by N.E. Putra, M.A. Leeflang, M. Minneboo, P. Taheri, L.E. Fratila-Apachitei, J.M.C. Mol, J. Zhou, A.A. Zadpoor. Acta Biomaterialia. May 2020

3D Printing In Orthopedics: Implants, Drug Delivery, Bone Regeneration

Bone Grafts: Inducing Bone Regeneration with 3D Printed Porosity

Bio Fabrication Techniques for Bone and Cartilage Tissue Regeneration

3D Bioprinting Bone – One Defect At A Time

An Introduction to Scaffolds for Tissue Engineering of the Bone and Cartilage