The latest advantages of utilizing 3D printing for the fabrication of microfluidic devices and organ-on-a-chip systems have opened up new horizons in biomedical research and personalized medicine. 3D printing offers precision and flexibility that traditional methods often cannot achieve, enabling the rapid and cost-effective production of intricate microscale structures that mimic the complexity of human organs and tissue environments. Researchers can now customize microfluidic devices to emulate specific physiological conditions, allowing for more accurate drug testing and disease modeling. Moreover, the ability to integrate multiple materials in a single print enables the recreation of tissue interfaces and vascular networks, fostering the development of more lifelike organ-on-a-chip platforms. This innovative approach promises to revolutionize drug development, toxicology testing, and disease understanding, offering a glimpse into a future where personalized medicine is driven by these advanced, 3D-printed microsystems. In this upcoming virtual event, 3DHEALS invites you to join world-class panelists and entrepreneurs to explore the future of this promising application together. #JoinTheTribe

Apply to speak or sponsor the event: info@3dheals.com

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Speaker:

Elliot McAllister

Elliot McAllister is the Founder of Skyphos, the first 3D printing fabrication system enabling a shift from the enterprise of mold-based prototyping and production for healthcare-based needs. Mr. McAllister has experience and expertise in Materials Science, Mechanical Engineering, Optics and developing microfluidic platforms. He has an advanced degree from Virginia Tech where his research focused on micro-3D printing 4 different forms of solid matter. Based on additive manufacturing technology, Mr. McAllister launched Skyphos to eliminate the barriers to entry of new applications in medical diagnostics and focuses on micro-scale requirements of microfluidics (uF), Lab-on-a-Chip (LOAC), Point-of-Care (POC) devices, as well as the needs of the sensors community. Skyphos leverages robotics, specialized materials, and the innate flexibility of a Digital Manufacturing platform to enable start-ups to get to market sooner – and large companies to reduce costs associated with developing new ones.

Natan Barros

I am a dedicated researcher with a passion for academic and translational research. My journey began with a bachelor’s degree in chemistry, where I developed a keen interest in biochemistry and polymers. Pursuing advanced studies in biotechnology at Sao Paulo State University (UNESP), one of Brazil’s leading institutions, I delved into biomaterials science and tissue engineering during my master’s and Ph.D. There, I focused on developing functional biomaterials for drug delivery and chronic wound healing. In 2019, I embarked on a transformative experience as a visiting researcher at the University of California, Los Angeles (UCLA) under the guidance of Dr. Ali Khademhosseini. At UCLA, I pioneered a microfluidic in vitro platform to model skin and explored innovative areas such as 3D bioprinting of functional skeletal muscle tissues and localized melanoma treatment. My dedication to groundbreaking research continued at the Terasaki Institute for Biomedical Innovation (TIBI), where I collaborated with esteemed mentors like Dr. Khademhosseini and Dr. HanJun Kim. Together, we investigated cutting-edge projects funded by NIH, including drug-eluting biomaterials for chemoembolization and bioengineered solutions for enterocutaneous fistula healing. Now, as a faculty fellow, I lead my research group at TIBI, focusing on shear-thinning hydrogels, microfluidic droplet platforms, and 3D bioprinted in vitro tissues.

Soon Seng Ng

Dr. Soon Seng Ng is an accomplished biomedical scientist and Director of Biology at Systemic Bio, leading groundbreaking research in 3D bioprinting and MPS development. With prior roles at Sana Biotechnology, Imperial College London, and Stanford University, Dr. Ng has made significant contributions in liver stem cell biology, disease modeling, drug discovery, and liver cell therapy. He has over 20 peer-reviewed publications, and his work has garnered awards and multi-million dollars grants, highlighting his impact on translational medicine and his commitment to bringing new therapies to patients. Dr. Ng’s dedication to advancing biomedical research and improving patient outcomes establishes him as a highly influential figure in the field.

Anna Bickham

Anna Bickham is the cofounder and CEO of Acrea 3D. Anna received her Ph.D. in chemistry from Brigham Young University in Dr. Adam Woolley’s lab, focusing on traditional and 3D printed fabrication of various medical and electrical microfluidic devices. She then spun Acrea 3D out of the technology used during her doctoral program, originating out of Dr. Greg Nordin’s lab. Acrea 3D specializes in micro-scale DLP-SLA printing of void features down to 20 um. By leveraging mechanical, software, and physical techniques, Acrea 3D enables true microfluidic 3D printing.

Moderator:

Dr. Jenny Chen

Dr. Jenny Chen is trained as a neuroradiologist, and founder/CEO of 3DHEALS. Her main interests include next-generation education, 3D printing in the healthcare sector, automated biology, and artificial intelligence. She is an angel investor who invests in Pitch3D companies.

Now on Demand:

The post 3D Printing Organ on a Chip, Microfluidics Devices 🗓 appeared first on 3DHeals.

Adam Jakus, Ph.D.: is the co-founder and Chief Technology of Dimension Inx LLC, a start-up developing transformative advanced manufacturing materials and processes for medical and non-medical spaces. Adam received his BS and MS degrees in Materials Science and Engineering from Georgia Tech, where he worked on the development and testing of new energetic material systems. In 2010, he began working at Northwestern University with Dimension Inx’s other co-founder, Ramille Shah, Ph.D. While at Northwestern, Adam invented and developed an entirely new, materials-centric approach to 3D printing and advanced manufacturing, now referred to as 3D-Painting, and hundreds of new 3D-printable materials for medical and non-medical purposes. These materials include, but are not limited to the high tissue and organ regenerative Hyperelastic Bone™, 3D-Graphene, Tissue Papers, and Fluffy-X. With approximately 10 years and many thousands of hours of bioprinting and tissue regenerative 3D-Printing experience, Adam leads the field, providing expertise to several not-for-profit bodies looking to establish guidelines, guidance, and certifications related to the emerging fields of tissue and organ fabrication. He is the author of numerous granted and pending patents, high-impact medical and non-medical publications, book chapters, and editorials related to advanced manufacturing and 3D printing of biomaterials and non-materials. Dr. Jakus will be a speaker at the upcoming 3DHEALS virtual event: NAMIC/3DHEALS Startup ShowCase

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Jenny: When was the first encounter you had with 3D printing? What was that experience like? What were you thinking at that moment?

Adam: My first experience with 3D-printing/additive manufacturing was back in late 2010/2011 as part of Prof. Ramille Shah’s newly established research lab at Northwestern University (no longer at Northwestern), when our group purchased one of the very first Manufacturing Series 3D-BioPlotters from EnvisionTEC. My initial thoughts were “This is really neat, but the materials currently compatible with the system are terrible for biological/clinical applications and just terrible in general” and “these materials that do exist are a real pain to print”. As a Materials Engineer, upon thinking that, I realized there was a major need and an opportunity to focus on developing new 3D-Printable materials of all kinds, not just biomaterials, that were not only highly functional (beyond materials for models or inert gels like alginates, celluloses, gel-Mas, etc.,  thermoplastics like PCLs, PLAs, PEEKs, etc., the endless variety of photopolymers, simple metals and alloys; all of which were still quite common in the field in the 2000s and early 2010s), but also very scalable, easy to implement, and infinitely versatile. That thought, combined with my prior 5-6 years research experience with creating structural thermites and other “energetic” materials, made me realize that were endless opportunities before me with this neat, but ultimately simple (just an X, Y, Z extruder) machine. These efforts resulted in the development of what is now referred to as the 3D-Paint and 3D-Painting technology platform – a exceptionally versatile means of designing and producing a near endless variety of 3D-printable materials (from biomaterials, to electronic materials, ceramics, metals and alloys, and every extraterrestrial materials), including what we now call Hyperelastic Bone™ (First demonstrated in 2011), 3D-Graphene, Fluffy-X™, Tissue Papers, 3D-Metals and 3D-Alloys, and more. As 3D-printing was becoming increasingly popular among industry and enthusiasts, it was clear there was a real need for new materials beyond those previously mentioned. Thus, Ramille Shah and I founded Dimension Inx in 2016 – with the goal of not only transforming medicine but also the broader manufacturing industry. 

Jenny: What inspired you to start your journey in 3D printing ?

Adam: As mentioned previously, I somewhat stumbled into it initially. Upon seeing a really advanced piece of 3D-Printing machinery with great hardware and software, but very limited materials capabilities, I saw an opportunity/unmet need. As I learned more about the field, I also thought it was crazy that so much effort was being spent on hardware and software related to 3D-Printing but not the actual material that was to be 3D-Printed. Even with the most advanced piece of machinery in the world, if you can only print inert plastics, simple metals, non-clinically relevant gels, what is the point? As the development of the new materials progressed, and as broader awareness and education of 3D-printing increased among researchers and industry, there was increasing demand from researchers, industry, and physicians, our new advanced 3D-printable materials – a demand we could not sustain as being part of a not-for-profit University. Thus, Ramille Shah and I founded Dimension Inx in 2016, where I Have been full time since 2017. 

Jenny: Who inspired you the most along this journey in 3D printing ? 

Adam: I can’t say that anyone, in particular, inspired me during this time. But the continuous affirmation from researchers, doctors, and industry that they really needed something different from the basic hydrogels, thermoplastics, photopolymers, and metals and alloys kept my energy high throughout the entire process. Also, it is incredibly exciting to hand a new material, in 3D-printed form, to a physician and see their excitement when they learn what it is and what it does – the number of ideas they generate when they realize, for example, that a bioceramic can be flexible and surgically friendly (or a flexible graphene patch can be rapidly produced), is inspiring.  These professionals have been stuck with existing materials for so long, they didn’t realize certain things were not only possible but now available. 

Jenny: What motivates you the most for your work? 

Adam: Two things motivate me the most. First, at my core, I am a materials engineer. In the same way, mechanical or electrical engineering might enjoy tinkering to create new pieces of machinery or electronics, I get substantial joy and fulfillment from tinkering with materials and processes to create new materials with properties that didn’t previously exist. That curiosity and seeing what I can do and how I can push materials motivates me intellectually. Second, at the end of my days of designing new materials, it is extremely motivating to know that they serve a real need and can potentially make the lives of others better or save their lives outright. One needs this real motivation on the medical side of things because it is a slow process to get it to patients, especially when you are talking about revolutionary new technologies.

Jenny: What is/are the biggest obstacle(s) in your line of work? If you have conquered them, what were your solutions? 

Adam: In medical 3D-Printing in general, I would say there are two major classes of obstacles: hype/undereducation and lack of relevant materials. On the first item, hype/undereducation, I, unfortunately, find myself having to correct misperceptions and poor knowledge primarily generated by social and traditional media. The lack of knowledge of the field, which is still not taught in most universities to science or engineering students (that needs to change), is pervasive among not only the general public but also academics, researchers, industry, investors, physicians, and others, in combination with easy means of sharing stories via social media, creates a very challenging environment and slows down the progression of the field. A broad example is equating surgical model 3D-printing, with advanced biomaterial (regenerative) 3D-printing, and bioprinting (printing lives cells and tissues). These are very different fields, with the first being around for ~30 years and approaching the standard of care in many places, and the latter, being older than most expect (the early 2000s). Because of this lack of awareness, even academic and industry researchers spend significant time and resources “reinventing the wheel” of technologies first established and tried in the early 2000s or even earlier. Additionally, lack of knowledge of the field among government funding organizations led to a big gap of funding in the early 2010s for advanced 3D-printing technologies (but they were being equated to surgical models). These organizations are finally beginning to fund research in this area, but missed a major opportunity in the early 2010s.

On the technical side of things, the major obstacle has always been materials. The common materials we see being 3D-printed in medicine today have been 3D-printed and applied for 20-30 years. They’re not new, nor is 3D-printing or additive manufacturing technology. Materials matter… a 3D-printed plastic heart, regardless of how many colors it has, may be good for surgical planning and education, but it would never be suitable as a substitution for the actual heart. Geometry the same, the difference in materials. The biological heart needs to be comprised of living materials or very highly bioactive materials that transform into living material in the presence of biological signaling. This is very different from plastic or even metal. As the field does become more educated, however, the realization that materials matter is becoming more and more prevalent and more and more materials engineers are joining the field. 

Jenny: What do you think is (are) the biggest challenge(s) in 3D Printing/bio-printing? What do you think the potential solution(s) is (are)?

Adam: See previous response. The biggest challenges, at the moment, are education/cutting through hype and misinformation, funding (connected to education), and lack of available materials. A first step would be to establish a certified university curriculum around Medical 3D-Printing, with two distinct tracts: surgical modeling, guides, permanent implantables, and advanced biomaterials and bioprinting. An additional step would be for those of us who are deep in the field to actively educate and counter inaccurate stories when we seem. Finally, a body of knowledge, certifications, and quality and standards need to be established – which is currently the focus of several major US national organizations. 

Jenny: If you are granted three wishes by a higher being, what would they be?  

Adam:

1. To have more time in the day.
2. To be able to know instantly if someone needs medical help and has problems that could be addressed by our materials.

Jenny: What advice would you give to a smart driven college student in the “real world”? What bad advice you heard should they ignore? 

Adam: Most important piece of advice I can give is “diversify your knowledge”. IF you want to go into bioprinting, get experience/education doing something else first (metallurgy, art, mechanical engineering, anything else), then get into the field. What is common, every day, and unremarkable in one field may be unheard of in another. It is important to bring that diversity into the field you want to pursue. If everyone in the same field has the same knowledge and training, how can the field expect to progress? Second, specifically for the world of 3D-printing (medical and non-medical), university education and research is typically farther behind what is known and already being done in the industry – this is quite unique to this field (it is usually the other way around). As such, I encourage students to go to industry shows and events rather than just academic/research events. You’ll be amazed at the differences in this field. 

Jenny: If you could have a giant billboard to promote a message to millions and even billions of people in our community (i.e. healthcare 3D printing and bio-fabrication), what message would that be? 

Adam: “Biofabrication: Let’s work together!” I say that because there are too many islands of efforts right now, with many groups reinventing the wheel or completely unaware of what is being done by other groups. The technology is there, the motivation is there, the need is there – it’s just a matter of education and communication at this point. 

Jenny: What were/was the best investment you made in 3D printing/bio-printing/bio-fabrication? 

Adam: Throwing my whole life behind new materials development for 3D-printing.

Jenny: What were/was the worst investment you made in 3D printing/bio-printing/bio-fabrication? 

Adam: Can’t think of one, other than possibly spending too much time of my time pursuing this while in academia. Academia is still catching up to where the technology actually is. 

Jenny: What was/is the biggest risk you took in your career?

Adam: Co-Founding and putting all my resources into our current company, Dimension Inx, despite having many other options on the table. It’s been risky, but I am so glad I did it!

Jenny: What do you enjoy in your spare time? What are you passionate about outside of your work/3d printing?

Adam: I am actually passionate about 3D-Printing outside of my work/3D-Printing 😊 I pursue art and cooking. I have an art company based on my 3D-printed pieces/technology. Art, like cooking, is not only a low-pressure way to explore new methods and approaches without care, but it is an excellent means of communicating to those outside of the hard technology fields. My art has been exhibited at several major international events and there are two museum events upcoming in May 2019 where some of my pieces (based around advanced biomaterial 3D-printing) will be exhibited. 

Jenny: What is your favorite quote? Why?

Adam: Two Quotes:

1. “Let the future tell the truth, and evaluate each one according to his work and accomplishments. The present is theirs; the future, for which I have really worked, is mine” ― Nikola Tesla

Because I am in a very difficult, emerging, potentially transformative field. There are so many obstacles to overcome and work to complete today, but I really do it for what that future might bring, where medical treatment and technology is transformed. 

2. “If I had an hour to solve a problem I’d spend 55 minutes thinking about the problem and five minutes thinking about solutions.” ― Albert Einstein

Because, as an engineer, with so many tools, materials, and skillsets at my fingertips, but so limited time, it is important to understand exactly what should be the focus of my efforts. There it a lot of good work and research that looks for a problem, but there are so many problems that aren’t the focused subject of work and research. 

Jenny: What does the word “3DHEALS” mean to you?  =)

Adam: It means more motivation. The field has been around a long time now but is finally beginning to pick up steam because of collective organizations, such as 3DHEALS, making the broader push.

Related Links:

Bone Grafts: Inducing Bone Regeneration with 3D Printed Porosity

3DHEALS2020 Session 17. Biofabrication Ecosystem

Interview with Adam Clark, Tangible Solutions

Bio Fabrication Techniques for Bone and Cartilage Tissue Regeneration

Interview: Professor Adam Feinberg, Carnegie Mellon University, CTO and co-founder FluidForm

The post Interview: Adam Jakus, Chief Technology of DimensionInx appeared first on 3DHeals.

3D printing for perioperative planning has been around since the birth of STL. However, the medical community has gone through many milestones, and this “From Academia” blog highlights three recent publications demonstrating how the surgical communities are reinventing old surgical techniques using new 3D technologies, racing from 3D printed soft anatomical models, new 3D software tools, finite element analysis, to artificial intelligence and cloud computing. The first article is a review focusing on different applications of 3D printing in breast cancer management, ranging from visualization help to surgical guides that may be more superior to conventional guidance to post-surgical radiation treatment guidance. The second article is a research paper focusing on creating streamlined workflow leveraging improved, more automated segmentation processes (for soft tissues) and soft material 3D printing technologies to create better neurosurgical planning by creating 3D printed patient-specific brain tumour models. The final paper describes the use of affordable 3D printing technology to produce ready-to-use, sterilizable auricular carving and framework sizing templates to guide the perioperative sculpture of the cartilaginous framework during microtia reconstruction, considered one of the most challenging procedures in the field of reconstruction surgery.

“From Academia” features recent, relevant, close to commercialization academic publications. Subjects include but not limited to healthcare 3D printing, 3D bioprinting, and related emerging technologies.

Email: Rance Tino ( info@3dheals.com ) if you want to share relevant academic publications with us.

Applications of 3D printing in breast cancer management

Authored by Arpine Galstyan, Michael J. Bunker, Fluvio Lobo, Robert Sims, James Inziello, Jack Stubbs, Rita Mukthar & Tatiana Kelil. 3D printing in Medicine. February 9 2021

Clinical application of patient-specific 3D printing brain tumor model production system for neurosurgery

Authored by Yun-Sik Dho, Doohee Lee, Teahyun Ha, So Young Ji, Kyung Min Kim, Ho Kang, Min-Sung Kim, Jin Wook Kim, Won-Sang Cho, Yong Hwy Kim, Young Gyu Kim, Sang Joon Park & Chul-Kee Park. Nature Scientific Reports. March 26 2021

Multiscale sterilizable 3D printed auricular templates to guide cartilaginous framework sizing and sculpture during autologous microtia reconstruction

Authored by Bushra Alhazmi, Feras Alshomer, Bassam Alawirdhi. JPRAS open. March 19 2021

Related Articles:

Medical 3D Printing for Surgery: Anatomical Models and Surgical Guides

3D Printing and Bioprinting For Cancer Care – Guide

3D Bioprinting for Bone Regeneration

From Academia: 3D Printing for Neurosurgery Training, Vat Photopolymerization, soft robotic microsystem

From Academia: In Vivo & Robotic-assisted Minimally Invasive Bioprinting, 3DP for Liver Surgery

Smart Spine Surgery- From Planning to 3D Printed Templates

The Past and Present of 3D Printing in Maxillofacial Surgery

Other Expert Corner Blogs

Other From Academia Blogs

The post 3D Printing for Perioperative Planning of Breast Cancer, Brain Tumor, and Microtia appeared first on 3DHeals.

In this issue of “From Academia“, we include four recent research publications related to “seeing”, including articles focusing on creating smart contact lenses, cornea, glass optics, and microscope leveraging 3D printing technologies. In the first article, researchers presented a way to develop hydrogel-based contact lenses that can have biosensing capabilities, including sensing eye blinking (peristaltic pressure), PH, and Na+ level, adding another tool to the future wearable market. In the second article, researchers demonstrated how additive manufacturing of gradient index (GRIN) silica-titania glass via direct ink writing method could potentially create a variety of conventional and unconventional optical functions in a flat glass component with no surface curvature. In the third article, the researchers described a way to create a 3D corneal stroma using an orthogonally oriented pure electro-compacted collagen (EC). The researchers believe this technique could potentially be used to create a future full-thickness corneal replacement. In the final article, the authors presented UC2 (You. See. Too.), a low-cost, 3D-printed, open-source, modular microscopy toolbox. The authors demonstrate its versatility by realizing a complete microscope development cycle from concept to experimental phase and developing an open standard in optics to facilitate interfacing with various complementary platforms. 

“From Academia” features recent, relevant, close to commercialization academic publications. Subjects include but not limited to healthcare 3D printing, 3D bioprinting, and related emerging technologies.

Email: Rance Tino (info@3dheals.com) if you want to share relevant academic publications with us.

Microengineered poly(HEMA) hydrogels for wearable contact lens biosensing

Authored by Yihang Chen, Shiming Zhang, Qingyu Cui, Jiahua Ni, Xiaochen Wang, Xuanbing Cheng, Halima Alem, Peyton Tebon, Chun Xu, Changliang Guo,  Rohollah Nasiri, Rosalia Moreddu, Ali K. Yetisen, Samad Ahadian, Nureddin Ashammakhi, Sam Emaminejad, Vadim Jucaud,   Mehmet R. Dokmeci  and  Ali Khademhosseini. Lab on a Chip. 13 October 2020

3D printed gradient index glass optics

Authored by Rebecca Dylla-Spears, Timothy D. Yee, Koroush Sasan, Du T. Nguyen, Nikola A. Dudukovic, Jason M. Ortega, Michael A. Johnson, Oscar D. Herrera, Frederick J. Ryerson and Lana L. Wong, Science Advances. 18 November 2020 

Biomimetic corneal stroma using electro-compacted collagen

Authored by Zhi Chen, Xiao Liu, Jingjing You, Yihui Song, Eva Tomaskovic-Crook, Gerard Sutton, Jeremy M.Crook, Gordon G.Wallace. Acta Biomaterialia, 1 September 2020 

A versatile and customizable low-cost 3D-printed open standard for microscopic imaging

Authored by Benedict Diederich, René Lachmann, Swen Carlstedt, Barbora Marsikova, Haoran Wang, Xavier Uwurukundo, Alexander S. Mosig & Rainer Heintzmann. Nature Communications. 25 November 2020

Related Articles:

From Academia: Bioprinted Cancer Models, Microprinted Imaging Probe, 3DTech for Congenital Heart Disease

From Academia: 3D Printed Lens, Silk as Biomaterial, Aspiration-assisted freeform bioprinting

From Academia: 3D Bioprined Dendritic Vascular Networks, Cornea, Alternative Drug Delivery

Product Liability : Biocompatible Materials in 3D Printed Products

The post From Academia: 3D Printing Contact Lenses, Optics, and Visualization appeared first on 3DHeals.

Designing low-cost and viable vasculatures and scaffolds are essential to the successfull upscale biofabrication of organs and medical devices in the future. In this week’s “From Academia”, we list three articles that explore #biofabrication #bioprinting techniques that may address current cost limitations. The first articles demonstrates a novel and inexpensive design of lab-on-a-chip microfluidic device consisting of channels fabricated via material extrusion 3D printing and polydimethylsiloxane (PDMS) microfluidic casting process. The second articles explores the development of a low-cost and tunable bioink for the material extrusion of vasculatures and scaffolds. The last article explores the use of Projection Microstereolithographic, to design and fabricate engineered biofilms for the study of microbes.

“From Academia” features recent, relevant, close to commercialization academic publications. Subjects include but not limited to healthcare 3D printing, 3D bioprinting, and related emerging technologies.

Email: Rance Tino (info@3dheals.com) if you want to share relevant academic publications with us.

Negligible-cost microfluidic device fabrication using 3D-printed interconnecting channel scaffolds

Authored by Harry Felton, Robert Hughes, Andrea Diaz-Gaxiola. PLOS ONE. February 3 2021

Engineering a Chemically Defined Hydrogel Bioink for Direct Bioprinting of Microvasculature

Authored by Ryan W. Barrs, Jia Jia, Michael Ward, Dylan J. Richards, Hai Yao, Michael J. Yost, and Ying Mei. Biomacromolecules. December 17 2020

Projection Microstereolithographic Microbial Bioprinting for Engineered Biofilms

Authored by Karen Dubbin, Ziye Dong, Dan M. Park, Javier Alvarado, Jimmy Su, Elisa Wasson, Claire Robertson, Julie Jackson, Arpita Bose, Monica L. Moya, Yongqin Jiao, and William F. Hynes. ACS Nano letters. January 28 2021

Related Articles:

Automated Bioprinting

3D Printed Drug Delivering Medical Devices

3D Printing Ceramic Implants

3D Bioprinting Knee, Aneurysm Model, 3D Organization Using Microfluidics

3D Printing Pharmaceuticals and Drug Delivery Devices

3D Bioprinting The Heart & Cardiovascular System

3DHEALS Guides (Collective) – This is where we dive deep into subjects that you will find helpful for your projects and career.

3DEALS Expert Corner (Collective) – This is where we invite field experts to write their perspectives in a first-person narrative. To write for this column, please email: info@3dheals.com

3DHEALS From Academia (Collective) – This section features recent, relevant, close to commercialization academic publications in the space of healthcare 3D printing, 3D bioprinting, and related emerging technologies.

Other similar articles

The post Low-cost Bioprinting of Microfluidics, Scaffolds and Biofilms appeared first on 3DHeals.

3D bioprinting skin applications including wound healing have been a focus of key biofabrication development. In this issue of “From Academia”, we include three publications studying just that. The first study develops a bioprinted skin patch with antimicrobial and wound healing properties using 3D bioprinting. The second study demonstrated improved physical and biological characteristics of fibrinogen hydrogel supplemented with decellularized human skin-derived extracellular matrix (dsECM). This hybrid hydrogel improves the cell viability and structural strength of bioprinted skin constructs, hence better-wound healing ability. The final study develops 3D-printed biomimetic wound dressings using melt eletronwriting technique and demonstrates a solution that could potentially reduce scar tissue formation while enhancing wound closure.

“From Academia” features recent, relevant, close to commercialization academic publications. Subjects include but not limited to healthcare 3D printing, 3D bioprinting, and related emerging technologies.

Email: Rance Tino (info@3dheals.com) if you want to share relevant academic publications with us.

Development of Bio-Active Patches Based on Pectin for the Treatment of Ulcers and Wounds Using 3D-Bioprinting Technology

Authored by Eleftherios G. Andriotis,Georgios K. Eleftheriadis,Christina Karavasili and Dimitrios G. Fatouros. MDPI Pharmaceutics. 6 January 2020

Decellularized Skin Extracellular Matrix (dsECM) Improves the Physical and Biological Properties of Fibrinogen Hydrogel for Skin Bioprinting Applications

Authored by Adam M Jorgensen, Zishuai Chou, Gregory Gillispie, Sang Jin Lee, James J Yoo, Shay Soker and Anthony Atala. MDPI Nanomaterials. 24 July 2020 

Convergence of 3D printed biomimetic wound dressings and adult stem cell therapy

Authored by Abbas Shafiee, Amanda S. Cavalcanti, navid T. Saidy, Dominik Schneidereit, Oliver Friedrich, Akhilandeshwari Ravichandran, Elena M De-Juan-Pardo, Dietmar W. Hutmacher. Biomaterials. January 2021

Related Articles:

3D Printed Drug Delivering Medical Devices

3D Printing Ceramic Implants

3D Bioprinting Knee, Aneurysm Model, 3D Organization Using Microfluidics

3D Printing Pharmaceuticals and Drug Delivery Devices

3D Bioprinting The Heart & Cardiovascular System

Machine Learning in 3D Printing and Bioprinting, a Collection of Recent Publications

3DHEALS Guides (Collective) – This is where we dive deep into subjects that you will find helpful for your projects and career.

3DEALS Expert Corner (Collective) – This is where we invite field experts to write their perspectives in a first-person narrative. To write for this column, please email: info@3dheals.com

3DHEALS From Academia (Collective) – This section features recent, relevant, close to commercialization academic publications in the space of healthcare 3D printing, 3D bioprinting, and related emerging technologies.

Other similar articles

The post 3D Bioprinting Skin Applications, Wound Healing appeared first on 3DHeals.

In this week’s issue of “From Academia”, we share with you three recent publications all focusing on 3D printed drug delivering medical devices that can be personalized. The first article presented the design and effectiveness of an antibiotics-loaded 3D printed personalized hearing aid. The second article presented five different 3D printing designs of biodegradable subcutaneous implants for drug delivery. The final article focuses on designing calcium phosphate-based bone scaffold that also has a controllable antimicrobial function.

“From Academia” features recent, relevant, close to commercialization academic publications. Subjects include but not limited to healthcare 3D printing, 3D bioprinting, and related emerging technologies.

Email: Rance Tino (info@3dheals.com) if you want to share relevant academic publications with us.

Anti-biofilm multi drug-loaded 3D printed hearing aids

Authored by María Vivero-Lopez, Xiaoyan Xu, Andrea Muras, Ana Oteroc Angel Concheiro, Simon Gaisford, Abdul W. Basit, Carmen Alvarez-Lorenzo, Alvaro Goyanes. Materials Science and Engineering: C. 1 February 2020

Development of a Biodegradable Subcutaneous Implant for Prolonged Drug Delivery Using 3D Printing

Authored by Sarah A. Stewart, Juan Domínguez-Robles , Victoria J. McIlorum ,Elena Mancuso, Dimitrios A. Lamprou,Ryan F. Donnelly and Eneko Larrañeta. MDPI Pharmaceutics. 30 December 2019 

3D printing of calcium phosphate scaffolds with controlled release of antibacterial functions for jaw bone repair

Authored by Huan Sun, Cheng Hu, Changchun Zhou, Lina Wu, Jianxun Sun, Xuedong Zhou, Fei Xing, Cheng Long, Qingquan Kong, Jie Liang, Yujiang Fan, Xingdong Zhang. Materials & Design. April 2020

Related Articles:

3D Printing Ceramic Implants

3D Bioprinting Knee, Aneurysm Model, 3D Organization Using Microfluidics

3D Printing Pharmaceuticals and Drug Delivery Devices

3D Bioprinting The Heart & Cardiovascular System

Machine Learning in 3D Printing and Bioprinting, a Collection of Recent Publications

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3DHEALS From Academia (Collective) – This section features recent, relevant, close to commercialization academic publications in the space of healthcare 3D printing, 3D bioprinting, and related emerging technologies.

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The post 3D Printed Drug Delivering Medical Devices appeared first on 3DHeals.

In this week’s issue of “From Academia”, we share with you three latest publications focusing on 3D printing ceramic implants from different angles. The first publication focuses on 3D printing ceramic bone implants using laser stereolithography. The second article describes a customized, purely synthetic, 3D-printed bioceramic implant to regenerate and restore large cranial defects with mature, well-vascularized bone, with a morphology, ultrastructure, and composition similar to those of native skull bone. The final article evaluates the accuracy and precision of in-office 3D printed dental implant surgical guides comparing three different commercially available systems.

“From Academia” features recent, relevant, close to commercialization academic publications. Subjects include but not limited to healthcare 3D printing, 3D bioprinting, and related emerging technologies.

Email: Rance Tino (info@3dheals.com) if you want to share relevant academic publications with us.

Design and Fabrication of Complex-Shaped Ceramic Bone Implants via 3D Printing Based on Laser Stereolithography

Authored by Alexander Safonov, Evgenii Maltsev, Svyatoslav Chugunov, Andrey Tikhonov, Stepan Konev, Stanislav Evlashin, Dmitry Popov, Alexander Pasko and Iskander Akhatov. MDPI Applied Sciences. 29 September 2020

In situ bone regeneration of large cranial defects using synthetic ceramic implants with a tailored composition and design

Authored by Omar Omar, Thomas Engstrand, Lars Kihlström Burenstam Linder,  Jonas Åberg, Furqan A. Shah, Anders Palmquist,  Ulrik Birgersson, Ibrahim Elgali, Michael Pujari-Palmer, Håkan Engqvist, and Peter Thomsen. PNAS. 12 October 2020 

Accuracy and precision of 3D-printed implant surgical guides with different implant systems: An in vitro study

Authored by Matthew Yeung, Aous Abdulmajeed, Caroline K.Carrico, George R. Deeb, Sompop Bencharit. The Journal of Prosthetic Dentistry. 23 October 2019

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The post 3D Printing of Bone implants appeared first on 3DHeals.

In this week’s “From Academia”, we share with you three related publications focusing on medical applications of augmented reality and 3D imaging. In particular, two later articles focus on radiology workflow design, treating kidney and prostate cancer, and spine surgery navigation.

“From Academia” features recent, relevant, close to commercialization academic publications. Subjects include but not limited to healthcare 3D printing, 3D bioprinting, and related emerging technologies.

Email: Rance Tino (info@3dheals.com) if you want to share relevant academic publications with us.

Applying Modern Virtual and Augmented Reality Technologies to Medical Images and Models

Authored by Justin Sutherland, Belec, Adnan Sheikh, Leonid Chepelev, Waleed Althobaity, Benjamin J. W. Chow, Dimitrios Mitsouras, Andy Christensen, Frank J. Rybicki, and Daniel J. La Russa. Journal of Digital Imaging. 13 September 2018

3D Printing, Augmented Reality, and Virtual Reality for the Assessment and Management of Kidney and Prostate Cancer: A Systematic Review

Authored by Nicole Wake, Jeffrey E. Nussbaum, Marie I. Elias, Christine V.Nikas, Marc A. Bjurlin. Urology. September 2020 

Augmented Reality Surgical Navigation in Spine Surgery to Minimize Staff Radiation Exposure

Authored by Edström, Erik, Burström, Gustav, Omar, Artur, Nachabe, Rami, Söderman, Michael, Persson, Oscar, Gerdhem, Paul, Elmi-Terander, Adrian. Spine. January 2020

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3D Bioprinting The Heart & Cardiovascular System

Machine Learning in 3D Printing and Bioprinting, a Collection of Recent Publications

3D Printing for Neurosurgery Training, Vat Photopolymerization, soft robotic microsystem

Open-Source 3D printed Medical Devices and New Sensor for COVID

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The post Medical Applications of Augmented Reality appeared first on 3DHeals.

In this week’s “From Academia”, we picked three recent publications around 3D printed medical devices against COVID-19 pandemic. The first article describes a “home-made” wifi-connected pulse oximeter that transmits live data to a patient’s family doctors. 3D printing was used for parts of this device. The second article highlighted some of the safety concerns, design considerations, waste generation and disposal, intellectual property and manufacturing regulations, and the sanitization of 3D-printed personal protective equipment. The final article described a 3D-printed nasopharyngeal swab collection simulator for COVID-19 testing. Comprehensive 3D files for printing and full instructions for manufacturing this simulator is freely available online via an open-access link in the article link.

“From Academia” features recent, relevant, close to commercialization academic publications. Subjects include but not limited to healthcare 3D printing, 3D bioprinting, and related emerging technologies.

Email: Rance Tino (info@3dheals.com) if you want to share relevant academic publications with us.

3D printing technology and internet of things prototyping in family practice: building pulse oximeters during COVID-19 pandemic

Authored by Matteo Capobussi & Lorenzo Moja. 3D Printing in Medicine. 2 November 2020

COVID-19: The Use of 3D Printing to Address PPE Shortage during a Pandemic—A Safety Perspective

Authored by Neelam Bharti and Shailendra Singh, ACS Chemical Health & Safety. 3 November 2020

3D-printed simulator for nasopharyngeal swab collection for COVID-19

Authored by Nicolas Sananès, Massimo Lodi, Antoine Koch, Lise Lecointre, Axel Sananès, Nicolas Lefebvre & Christian Debry. European Archives of Oto-Rhino-Laryngology, 6 November 2020 

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The post 3D Printed Medical Devices Against COVID, IoT Pulse Oximeters, Nasophayrengeal Swab Simulator, PPE Safety Concerns appeared first on 3DHeals.