From Academia: Bioprinting of Synthetic and Natural Bioinks

In this “From Academia” blog, we focus on a key ingredient for successful bioprinting, the bioinks. The first article is a recently published review that will lay the foundation of various bioprinting methods and focus on the natural, synthetic, or hybrid materials used as bioinks. This article also addresses the bioprinting technique’s challenges, limitations, and future directions. The second article explores how bioprinting and organoid technology can be merged to generate centimetre-scale tissues that have self-organized features, including lumens, branched vasculatures, and tubular intestinal epithelia with in vivo-like crypts and villus domains. This method could potentially be used to produce larger functional tissue with more geometry and cellular control. The third article introduces a new hydrogel bioink composed of partially digested, porcine cardiac decellularized extracellular matrix (cdECM), Laponite-XLG nanoclay, and poly(ethylene glycol)-diacrylate (PEG-DA). Here, the researchers show that 3D printed constructs with this new bioink demonstrate shape fidelity, adaptability to different printing conditions, and high cell viability following extrusion and photo-polymerization, highlighting the potential for applications in modelling both healthy and fibrotic cardiac tissue. 

From Academia” features recent, relevant, close to commercialization academic publications. Subjects include but not limited to healthcare 3D printing, 3D bioprinting, and related emerging technologies.

Email: Rance Tino ( if you want to share relevant academic publications with us.

Natural and Synthetic Bioinks for 3D Bioprinting

Authored by Dr. Roghayeh Khoeini  Dr. Hamed Nosrati  Dr. Abolfazl Akbarzadeh  Dr. Aziz Eftekhari  Dr. Taras Kavetskyy  Prof. Rovshan Khalilov  Dr. Elham Ahmadian  Dr. Aygun Nasibova  Dr. Pallab Datta  Dr. Leila Roshangar  Dr. Dante C. Deluca  Dr. Soodabeh Davaran  Prof. Magali Cucchiarini  Prof. Ibrahim T. Ozbolat. Advanced Nanobiomed Research. March 30 2021

Recapitulating macro-scale tissue self-organization through organoid bioprinting

Authored by Jonathan A. Brassard, Mike Nikolaev, Tania Hübscher, Moritz Hofer & Matthias P. Lutolf. Nature Materials, September 21 2020

3D bioprinting of mechanically tuned bioinks derived from cardiac decellularized extracellular matrix

Authored by Yu Jung Shin, Ryan T. Shafranek, Jonathan H. Tsui, Jelisha Walcott, Alshakim Nelson, Deok-Ho Kim. Acta Biomaterialia. January 1 2021

From Academia: Tweaking Bioinks Palette, One-Drop 3D Printing

From Academia: Nanoclay Bioink, Machine Learning, Hydrogel Design Strategies for 3D Bioprinting

3D Bioprinting: The Yellow Brick Road of (Part 1)

From Academia: Tweaking Bioinks Palette, One-Drop 3D Printing