May 03, 2021 In this “From Academia” blog, we focus on a key ingredient for successful bioprinting, the bioinks. The first article is a recently published review that will lay the foundation of various bioprinting methods and focus on the natural, synthetic, or hybrid materials used as bioinks. This article also addresses the bioprinting technique’s challenges, limitations, and future directions. The second article explores how bioprinting and organoid technology can be merged to generate centimetre-scale tissues that have self-organized features, including lumens, branched vasculatures, and tubular intestinal epithelia with in vivo-like crypts and villus domains. This method could potentially be used to produce larger functional tissue with more geometry and cellular control. The third article introduces a new hydrogel bioink composed of partially digested, porcine cardiac decellularized extracellular matrix (cdECM), Laponite-XLG nanoclay, and poly(ethylene glycol)-diacrylate (PEG-DA). Here, the researchers show that 3D printed constructs with this new bioink demonstrate shape fidelity, adaptability to different printing conditions, and high cell viability following extrusion and photo-polymerization, highlighting the potential for applications in modelling both healthy and fibrotic cardiac tissue.
“From Academia” features recent, relevant, close to commercialization academic publications. Subjects include but not limited to healthcare 3D printing, 3D bioprinting, and related emerging technologies.
Email: Rance Tino (info@3dheals.com) if you want to share relevant academic publications with us.
Natural and Synthetic Bioinks for 3D Bioprinting
Authored by Dr. Roghayeh Khoeini Dr. Hamed Nosrati Dr. Abolfazl Akbarzadeh Dr. Aziz Eftekhari Dr. Taras Kavetskyy Prof. Rovshan Khalilov Dr. Elham Ahmadian Dr. Aygun Nasibova Dr. Pallab Datta Dr. Leila Roshangar Dr. Dante C. Deluca Dr. Soodabeh Davaran Prof. Magali Cucchiarini Prof. Ibrahim T. Ozbolat. Advanced Nanobiomed Research. March 30 2021
Recapitulating macro-scale tissue self-organization through organoid bioprinting
Authored by Jonathan A. Brassard, Mike Nikolaev, Tania Hübscher, Moritz Hofer & Matthias P. Lutolf. Nature Materials, September 21 2020
3D bioprinting of mechanically tuned bioinks derived from cardiac decellularized extracellular matrix
Authored by Yu Jung Shin, Ryan T. Shafranek, Jonathan H. Tsui, Jelisha Walcott, Alshakim Nelson, Deok-Ho Kim. Acta Biomaterialia. January 1 2021
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From Academia: Tweaking Bioinks Palette, One-Drop 3D Printing
From Academia: Nanoclay Bioink, Machine Learning, Hydrogel Design Strategies for 3D Bioprinting
3D Bioprinting: The Yellow Brick Road of (Part 1)
From Academia: Tweaking Bioinks Palette, One-Drop 3D Printing
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