From Academia: Optimizing Bioprinting Hydrogel using Machine Learning, Modified or Decellularized ECM

Bioprinting organs cannot succeed without the right biomaterials. In this issue of “From Academia”, three articles focus on different ways to optimize bioprinting hydrogel. The first article focuses on using machine learning with various parameters to optimize FRESH technique with alginate. This is one of few articles exploring the future scaling of automated biofabrication and tissue engineering. The second study explores an application using 3D bioprinting optimized methacrylated HA (MeHA), a modified major component of extracellular matrix (ECM) to create in vitro testbeds for studying neural repair. The final article goes a step further by using 3D printed esophageal derived decellularized ECM hydrogel-loaded stent to treat radiation esophagitis in the animal models.

From Academia” features recent, relevant, close to commercialization academic publications. Subjects include but not limited to healthcare 3D printing, 3D bioprinting, and related emerging technologies.

Email: Rance Tino ( if you want to share relevant academic publications with us.

Hierarchical Machine Learning for High-Fidelity 3D Printed Biopolymers

Authored by Jennifer M. Bone, Christopher M. Childs, Aditya Menon, Barnabás Póczos, Adam W. Feinberg, Philip R. LeDuc, and Newell R. Washburn. ACS Biomaterials Science & Engineering. 20 November 2020

Three-Dimensional Bioprinted Hyaluronic Acid Hydrogel Test Beds for Assessing Neural Cell Responses to Competitive Growth Stimuli

Authored by Tran B. Ngo, Benjamin S. Spearman, Nora Hlavac, and Christine E. Schmidt, ACS Biomaterials Science & Engineering. 1 December 2020 

Therapeutic effect of decellularized extracellular matrix-based hydrogel for radiation esophagitis by 3D printed esophageal stent

Authored by Dong-HeonHaab, Suhun Chaea, Jae Yeon Lee, Jae Yun Kim, Jung bin Yoon, Tugce Sen, Sung-Woo Lee, Hak Jae Kim, Jae Ho Cho, Dong-Woo Cho. ACS Applied Materials & Interfaces. 20 January 2021

3D Bioprinting Personalized Brain Tissues

3D Bioprinting Skin Applications, Wound Healing

Meeting Cell Demands for Tissue Engineering and Bioprinting

Medical Simulation Using Augmented Reality, Virtual Reality, 3D Printing

3D Printing in Veterinary Practice

3D Printing In Orthopedics: Implants, Drug Delivery, Bone Regeneration

3D Printing Pharmaceuticals and Drug Delivery Devices

3DHEALS Guides (Collective) – This is where we dive deep into subjects that you will find helpful for your projects and career.

3DEALS Expert Corner (Collective) – This is where we invite field experts to write their perspectives in a first-person narrative. To write for this column, please email:

3DHEALS From Academia (Collective) – This section features recent, relevant, close to commercialization academic publications in the space of healthcare 3D printing, 3D bioprinting, and related emerging technologies.

Other similar articles