Bioprinting

3D Printing and Bioprinting Bones

3D printing and bioprinting to regenerate bone both are promising for the regeneration of bone tissue. It uses 3D printing to create acellular scaffolds or 3D bioprinting bio-inks that contain living cells and growth factors to promote bone growth. This technology has the potential to create exact replicas of damaged bone, which could then be implanted in the body to help regenerate lost tissue. The process begins with scanning the bone defect to create a 3D model of the desired bone structure. Then, biomaterials or bio-ink containing stem cells and growth factors are printed in the desired structure based on the 3D models. The scaffold acts as a supportive structure for the cells, which are then allowed to grow in the desired shape. Once the cells have grown and matured, they can then be implanted into the patient’s body. This technology has been successfully used to regenerate bone in animals and is now being tested in human clinical trials. Some of the forerunners in the field include Osteopore (Singapore), Ossiform(Denmark, previously known as Particle 3D), DimensionInx(U.S., Chicago), and Cerhum(Belgium). In this upcoming virtual event, we invite all stakeholders with different backgrounds to learn and participate focusing on how we can use 3D printing to regenerate bone tissues.

Speakers:

Raphael Lichtnecker

Raphael Lichtnecker

I got my Master´s degree in Pharmaceutical Bioprocess Engineering at Technical University Munich. Afterwards I started as Business Development Manager at ViscoTec where I am responsible for the technology transfer of the progressive cavity pump to the bioprinting sector. I´m in this position for almost five years now.

Elisabeth Cobraiville

Elisabeth is a biomedical engineer specialized in biomaterials. She also holds a university certificate in Quality, Regulatory and Clinical Affairs of medical devices. Prior to joining CERHUM, she worked in a CRO and managed preclinical and clinical trials. She joined CERHUM almost 4 years ago and she is in charge of the products technical file, animal studies and clinical trials.

Daniel Kelly

Prof Daniel Kelly leads a multidisciplinary musculoskeletal tissue engineering group based in the Trinity Centre for Biomedical Engineering. The goal of his lab is to understand how environmental factors regulate the fate of adult progenitor cells and the tissues they produce. This research underpins a more translational programme aimed at developing novel tissue engineering and 3D bioprinting strategies to regenerate damaged and diseased musculoskeletal tissues. To date he has published over 200 articles in peer-reviewed journals. He is the recipient of four European Research Council awards (Starter grant 2010; Consolidator grant 2015; Proof of Concept grant 2017; Advanced grant 2021).

Denys Gurak

Denys Gurak is an experienced C-level manager and serial entrepreneur. He is a CEO and Co-Founder at A.D.A.M., a 3D bioprinting company with a primary focus on 3D-printed bones. Denys’s ultimate vision is to build an on-demand personalized tissue manufacturing platform that would be a one-stop shop for transplanted tissues and organs; and, hence, to cut barriers to medical treatment for millions. Denys’s passion for biotech can be traced back to 2010, when he was leading the international relations and certification, along with EU legislation adaptation at the Ukrainian medicinal products regulatory authority (official position – director of the «GMP/GDP Center» of the State Administration of Ukraine on Medicinal Products (SAUMP). In 2014 Denys joined the Ukrainian Defense Industry (a state defense conglomerate) in 2014 as the Deputy Director-General for foreign economic activity. During his time at the company, he managed the export-import operations that amounted to USD 1 billion yearly turnover. Furthermore, Denys represented Ukraine as the Head of Ukraine’s delegation to the NATO Industrial Advisory Group (NIAG), and led the industry transformation initiatives, including innovations development and technology JVs, as well international relations. Denys is a Venture Partner at ff Venture Capital a high-performing early stage venture firm based in NYC and Warsaw, Poland, focusing on disruptive IT, biotechnology, aerospace and security projects in CEE region.

Dan Rogozea

Dan Rogozea started working in the bioprinting field with the mission to produce the smallest bones in the human body, the ossicles. This project started in 2018 and initiated his work in the bioprinting field. In collaboration with Dr. Moldovan at the Roudebush VA Medical Center Bioprinting Core, he has continued to work in multiple projects in different fields ranging from cardiovascular to dental bioprinting projects. As an expert in the field Dan Rogozea continues to work in research and for well -known bioprinting companies.

Moderator:

Dr. Jenny Chen

jenny chen

Dr. Jenny Chen is trained as a neuroradiologist, and founder/CEO of 3DHEALS. Her main interests include next-generation education, 3D printing in the healthcare sector, automated biology, and artificial intelligence. She is an angel investor who invests in Pitch3D companies.

Point of Care 3D Printing

Point of care 3D printing is becoming one of the biggest attractions in adopting 3D printing in healthcare systems because it demonstrates the ability to decentralize manufacturing personalized medical devices. The medical devices can range from anatomical modeling, and implants, to surgical guides based on the latest updates from all over the world. However, for companies interested in expanding markets either locally or regionally, understanding the complex relationships among different players and regulations are critical.

At the end of 2021, the FDA published its discussion paper on the subject, inviting the public to submit comments so that more clarifying regulatory guidance can be created.

Speaker:

Ido Bitan

Ido Bitan is a Product Manager in Stratasys’s Medical Solutions Department. Mr. Bitan received a Bachelor of Science in biomedical engineering from Beer Sheva University in Israel. Mr. Bitan began his career at a start-up company, where he worked as part of the Research & Development team to develop new cancer-detecting equipment that assists surgeons in the operating room. Mr. Bitan has helped establish Stratasys’s adaption to the medical industry, leading the development of the Digital Anatomy Printer, Digital Anatomy Creator, and many more of the accompanying materials and software features. The Medical Department at Stratasys continues to push the boundaries of technology to improve patient care worldwide, and Mr. Bitan is passionate about improving the healthcare system to ensure better outcomes for any patient.

Martin Herzmann

Martin Herzmann started his medtech career in 1999 at Brainlab Headquarter in Germany. After wworking positions in Sales, Product Management and Business Development, he joined Ziehm Imaging in 2007 and worked for another eight years as Marketing Director for medical capital equipment. In 2015, he joined the Materialise and transformed his past experiences into medical 3D printing. In 2019, Martin joined Kumovis as Business Development Manager. The company enables medical device companies and hospitals to manufacture 3D printed implants, instruments and guides following regulatory standards and norms. Kumovis has a clear focus on medical 3D printing with high-performance polymers and biodegradable polymers. With the merger of Kumovis and 3D Systems in April 2022 Martin now can focus even more on additive manufacturing at Point-of-Care and accelerates the global implementation of clinical applications such as cranial implants printed in PEEK.

Kerim Genc

Kerim Genc

Kerim Genc is the Business Development Manager for the Simpleware Product Group at Synopsys. He joined Simpleware in 2011 as a Technical Sales Consultant and is currently responsible for managing global sales, business development and partnerships. He received his BS and MS in biomechanics from the University of Calgary and the Pennsylvania State University respectively and completed his PhD in Biomedical Engineering at Case Western Reserve University looking at countermeasures to spaceflight induced bone loss and fracture risk.

Silvina Zabala-Travers

Silvina Zabala-Travers

– MD and Radiologist Degree from Universidad de la República (UdelaR) in Uruguay – 3D training at Sant Joan de Déu Hospital 3D Lab (Expert3D and internship) in Barcelona, Spain Dr Zabala-Travers introduced 3D technologies to the academic medical field in Uruguay in 2019 and has since pioneered its development with particular interest in training radiologists to be part of the workflow to ensure process precision. She founded and leads the Surgical Virtual Planning and 3D Printing Area at the Radiology Department Pereira Rossell Hospital Center, a state and university laboratory for the application of 3D technologies in diagnostics, surgical virtual planning, clinical simulation and education for pediatric and adult patients. She recently teamed-up with a custom-implant manufacturer to co-found UPGRADE Medicals, a healthcare 3D-technology start-up which provides anatomical biomodels, virtual planning with surgical guide design and custom implant in metal, PEEK and bioabsorbable materials. She is invited professor at the Expert3D course and has given many conferences sharing her experience implementing a hospital 3D lab in a low-resource facility, as well as hands-on training on segmentation, biomodeling and virtual planning for bioengineers and surgical specialists.  She presides the Latin American Society of Pediatric Radiology (SLARP) New Technologies Committee, a network for the implementation of 3D technologies in Latin American countries. She also works as Radiology Section Editor for the Elsevier Journal Annals of 3D Printed Medicine, currently Guest Editor for the Special Issue “Virtual Planning and Personalized Medicine”.

Moderator:

Dr. Jenny Chen

jenny chen

Dr. Jenny Chen is trained as a neuroradiologist, founder/CEO of 3DHEALS. Her main interests include next generation education, 3D printing in the healthcare sector, automated biology, artificial intelligence. She is an angel investor who invests in Pitch3D companies.

3D Printing for O&P, Assistive Devices

The field of 3D printed orthotics and prosthetics has advanced significantly since the days of ENABLE hands. These advancements include not just hardware, and materials, but also software, designs, 3D scanning, and lately completely digitalized workflow at the point of care, often leveraging machine learning and artificial intelligence. More importantly, technologists are now working more closely with clinicians to create a more efficient and more evidence-based patient-centered clinical solution. Join a group of entrepreneurs next Thursday and explore the latest update, challenges, and solutions to 3D printed orthotics, prostheses, and assistive devices. 

Speakers:

Diana Hall

Diana Hall graduated from Colorado School of Mines in 1997 with a degree in Chemical Engineering, and has worked in process engineering and software for Fortune 500 companies across the country. She completed her MBA at Colorado State University in Fort Collins in 2007, worked as a Business Development Director for nonprofits, and founded a mentoring program for children in poverty. Diana holds patents on 3D-printed exoskeletons, and founded ActivArmorTM in 2014. Diana has established partnerships with professional athletes, medical specialists, research hospitals and business leaders to develop custom medical and sports products. Diana was named Colorado Manufacturing Woman of the Year in 2022, and has won many business awards including the Small Business of the Year award, the Southern Colorado Entrepreneurship Competition’s Social Entrepreneurship award, the regional InnovateHER competition, Nationwide Insurance’s national $100,000 Pitch To Win competition, and is listed as Top 100 Colorado Manufacturers. She has spoken at several venues on the topic of 3D design and printing, small business ownership and start-ups, economic development and entrepreneurship, and has given a TEDx talk on the future of mass customization in design and manufacturing in 2015.

ActivArmorTM is now a global biomedical company, with 5 international contracts and more than $2.2M in investment. It is the first Pueblo company to be awarded the Colorado Office of Economic Development’s Advanced Industries Grant, bringing more than $250,000 in state funding to Pueblo for primary job creation in the areas of bio-science and advanced manufacturing. ActivArmorTM casts are being worn by professional athletes, including NFL players, and holds contracts with leading orthopedic clinics across the country, including Jacksonville Orthopedic Institute (the official sports medicine provider for the Jaguars, Sharks, Blue Wave and Armada), St. Lukes Hospital Network, and Children’s Hospital Colorado. ActivArmor is now available in 10 countries. A full list can be found on their website at www.ActivArmor.com.

Read Diana’s interview with us: https://3dheals.com/interview-with-diana-hall-activearmor-tm/

Florian De Boeck

Florian De Boeck is a serial entrepreneur who has always felt the urge to build and create. He has a master’s degree in biomedical engineering from the Politecnico di Milano, in Italy. At the age of 21, he started working for Engineer Without Borders in Madagascar, Congo, and Burundi. The objective was to help hospitals improve their waste management. After this first professional experience, Florian decided to set out to apply 3D printing technology to orthopedics. Florian is the co-founder of Spentys, a medical platform enabling healthcare providers to create patient-specific orthoses and prostheses cheaper and faster, thanks to 3D technologies. Today, Spentys has around 30 employees, has raised VC money, and is quickly growing. The solution is now available in more than 20 countries around the world and is used on a daily basis by more than 100 medical professionals. Florian has also launched a coworking space in Brussels (SanoHub, meaning the Healthy Hub) and has re-started the Family Brewery with his brothers and sister (De Boeck Family Brewery). Florian is still active and traveling for Engineer Without Borders during his free time.

Read Florian’s interview with us: https://3dheals.com/interview-with-florian-de-boeck-spentys/

Jacopo Lazzaro

Architect since 2012. Startups founder with focus on 3D scanning and 3D data interpretation and design. He has been freelance designer, web designer and graphic designer. Teacher of 3D modeling, 3D making and occasional developer. In 2014 he designed his first 3D printed cast and patented several ideas related to the 3D world among which PlayCast instantaneous 3D scanner. Today CEO and technical director and proud father of two little girls (and a cat).

Read Jacopo’s interview with us: https://3dheals.com/interview-with-jacopo-lazzaro-playcast/

Alexander Geht

Alexander is an experienced industrial designer with a background in practical electronics engineering. Alexander worked in the military, health care, design, and manufacturing fields with an Interest in human-centered design, research, and development(R&D), emphasis on assistive technology. Last ten years Alexander focuses on Digital and Additive Manufacturing (AM), and focuses on the design of adaptive products, creating innovative and affordable products. Alexander is a founder of ‘testa-seat’ which simplify complex manufacturing process to make seating systems affordable.

Moderator: 

Dr. Jenny Chen

jenny chen

Dr. Jenny Chen is trained as a neuroradiologist, founder/CEO of 3DHEALS. Her main interests include next generation education, 3D printing in the healthcare sector, automated biology, artificial intelligence. She is an angel investor who invests in Pitch3D companies.

Biomaterials for 3D Printing

Biomaterial science is one of the major pillars of the successful advancement of 3D printed solutions for healthcare. In this webinar, we invited stakeholders from academia, industry, larger chemical and material companies, and rising startups to give you a comprehensive view of where material science technology for healthcare 3D printing is at. We aim to provide information with enough breadth and depth that is suitable for both the general public and industry experts.

Speakers:

Guillaume de Calan

Guillaume de Calan is founder and CEO of Nanoe, a leading supplier of high tech raw materials for the ceramic industry. Through our brand Zetamix, he also launched the first line of filaments for accessible 3D printing of ceramic and metal parts. At Nanoe, we believe material innovation is at the core of new emerging technologies such as 3D printing, Li Ion batteries, medical implants and many more, and we strive to develop and produce best in class raw materials for these applications.

Rao Bezwada

RAO BEZWADA

An accomplished scientist and entrepreneur, Rao S. Bezwada, Ph.D. established Bezwada Biomedical LLC, an innovation based and technology driven company. The company is focused on developing a wide range of novel absorbable polymeric biomaterials that represent platform technologies capable of enhancing the quality of life by producing next generation bioabsorbable medical devices with therapeutic applications. Dr. Bezwada is the inventor of numerous absorbable technologies including absorbable polyurethanes, absorbable amino acid polymers, absorbable polyester amides, absorbable polyoxaesters and controlled release polymers. Dr Bezwada’s absorbable polyurethane technology is used in FDA approved products, MONTAGE®, MONTAGE Fast Set Putty, Montage Flowable Putty and PERMATAGE Putty which has been commercialized by Abyrx corporation. In addition, our absorbable polymers are used as bioinks, adhesion prevention barriers, absorbable drug eluting stent coatings, tissue adhesives and sealants, medical device coatings, drug delivery polymers, drug device combinations, absorbable implantable devices and tissue engineering biomaterial scaffolds. Bioinks innovation is one of our specialties. We offer a portfolio of bioinks that consists of PEG Acrylates, PEG Methacrylate’s, PEG Acrylamides, functionalized PEGs and copolymers of PEG with PLGA and Caprolactone. These bioinks can be customized to meet the needs to the customers including molecular weight, viscosity etc. If you’re looking for specialty polymers for 3D printing, please get in touch to discuss your application requirements.

Caroline Lauret 

Caroline Lauret joined Evonik in 2018 as a Senior Business Manager for Medical Devices. Caroline’s expertise lies in the field of medical device applications and she has been active in this market for more than 15 years. Caroline studied Biomedical Engineering at the Technical University Eindhoven, the Netherlands, and obtained her Master’s degree in Material Sciences. She has a strong background in global sales management, Medical Devices, Polymer Technology, and Materials Science.

Thiago Borges

Dr. Thiago Borges is manager for customer projects at Evonik’s biomaterials center in Birmingham, Alabama. He has 13 years of experience in the medical device industry and is responsible for managing customer projects, providing technical application support, and managing internal innovation projects for medical device solutions. Thiago joined Evonik in 2015 and was previously a project manager for RESOMER® Filament and other products where he coordinated the development of technical grade and GMP grades for this product. Prior to Evonik, he worked for eight years in the medical device industry holding different positions in R&D and operations, in particular working with stents and embolization devices. Thiago holds a bachelor’s degree in Chemistry from University of Sao Paulo, and a PhD in Polymer Science & Engineering from Case Western Reserve University in the U.S.

Ben Hartkopp

Ben Hartkopp is an inventor and co-inventor of a new kind of 3D printing system capable of jetting extremely viscous materials. The first application that this system addresses is printing photorealistic, full dentures in a single process with a far less post process than current systems on the market. He currently focuses on patent writing and strategy, test design, and research and development.

Moderator:

Dr. Jenny Chen

jenny chen

Dr. Jenny Chen is trained as a neuroradiologist, founder/CEO of 3DHEALS. Her main interests include next generation education, 3D printing in the healthcare sector, automated biology, artificial intelligence. She is an angel investor who invests in Pitch3D companies.

Healthcare 3D Printing Ecosystem: India

In this lightning round, we would like to connect experts from the Indian healthcare 3D printing ecosystem with 3DHEALS audiences around the world, highlighting their breakthroughs, and entrepreneurial lives, and opening new conversation channels on partnerships. We have curated a group of highly diverse and representative panelists from dental 3D printing, medical 3D printing, and bioprinting space. While it is impossible to really dive deep into the entrepreneurial culture and ecosystem of the community without actually physically being there, we aim to bring the most influential voices to the virtual event to give everyone a taste of what it is like to invest in, work for, and partner with Indian startups in the space.

Speaker:

Mahesh Kappanayil

Dr.Mahesh Kappanayil is a Professor of Pediatric Cardiology at Amrita Institute of Medical Sciences and Research Center, Kochi, Kerala, India. He is also the founder and lead of the 3D Printing, Virtual Reality and Innovation Laboratory at Amrita. As a pediatric cardiologist, he has been involved with various facets of the field including high-end transcatheter interventions, advanced cardiac imaging and clinical research. He helped establish India’s first dedicated cardiac MRI program for congenital heart diseases at Amrita. He has been involved in exploring the application of 3D+ technologies in Healthcare for well over a decade. In 2015-16 he helped establish the region’s first “Point-of-Care” medical 3D printing Lab at Amrita, and in 2020-21 expanded the scope of the lab to Extended Reality applications for medicine. These Labs today are hub of multi-disciplinary innovations in leveraging 3D+ technologies for healthcare applications. He believes that technology is a great equaliser, and cutting-edge technologies of 3D Printing and Extended Reality are set to revoutionalise medicine and healthcare in a big way, even in limited resource environments. Dr.Mahesh has won several national awards and recognitions for his work in this area, and has numerous expert lectures and publications to his credit.

Piyush Padmanabhan

Piyush’s journey into the world of Bioprinting began with his experience in the organ transplantation sector. Post his under graduation from Vellore Institute of Technology, Piyush began his career in the pharmaceutical sector at Biocon Limited and then at Roche Pharmaceuticals, where he worked closely with physicians and transplant coordinators in Kidney and Liver Transplants. The ever-widening gap in organs available for transplant and the need for these organs was very apparent to him. This led him to begin Next Big Innovation Labs® with Alok and Pooja, the other two co-founders of the company. In his role as the CEO and Co-Founder of Next Big Innovation Labs®, Piyush has led various deep technology projects in bioprinting and has also played a pivotal role in raising central and state government funding for the company. Some of the projects he has led are the following: the development of India’s first customized 3D Bioprinter, the development of unique temperature control fixtures for diverse bioprinting components and AI/ML integration into Trivima Bioprinting Systems. Piyush currently holds two technology patents and one process patent in the domain of bioprinting and considers himself to be an eternal student. His goal is to one day bridge the gap in the organ transplantation sector and believes in deep collaborations to achieve this goal.

Mahesh Dhoka 

I have done post my bachelors, taxation, and law along with business management. later joined family business where we are making high purity iron powders and flakes for food, pharma, aerospace and engineering industries exporting to about 30 countries across the world. started 3D Incredible in 2017 with an idea to bring this technology to the masses in India specially with respect to medical applications. so far we have done close to 1400 implants across more than 30 cities in India working and promoting 3d printing with close to 700 surgeons. with respect to engineering, we work with companies across various sectors right from prototyping to small batch production.

Yearla Srinivasa Rao

Yearla Srinivasa Rao is presently working as a chief operating officer of Medoja Health Private Limited, which is a healthcare company with a focus on 3D printing of patient-specific bespoke customized implants using novel biomaterials, and manufacturing of biomaterials from natural sources for medical 3D printing applications. Bone defects are filled with ceramic granules traditionally in many cases, without considering the shape fidelity to the defect or providing vascular supply. Medoja addressed this by using a ceramic composition which can be 3D printable to address shape fidelity and generate vascular supply to it. Yearla completed his Ph.D. from the University of Hyderabad and has overall 6+ years of post PhD industrial experience in nanomaterials and biomaterials based product development for agriculture, cosmetic, nutraceuticals, and pharmaceutical industries. He managed project activities from BIRAC and DBT during his tenure in the industry along with working in a multidisciplinary environment to manage sales, marketing, production, and business development, teams.

Dr. Jatin Kakrani

Co-Founder – Smiles.ai 

Certified Dental Implant & Digital dentistry trainer 

DCI accredited speaker 

Gold Medalist Prosthodontist |

Moderator: 

Firoza Kothari

Firoza Kothari, Co-Founder & CTO – Anatomiz3D Medtech Pvt. Ltd. – A B.Tech in Biotechnology Engineering and now Forbes 30 under 30 – Asia – Healthcare and Science, 2020, Firoza Kothari started her journey to provide patient-specific medical solutions and one day end the organ donation problem by creating live organs out of patients’ stem cells. With that aspiration, she gave birth to Anatomiz3D, a startup focusing on medical 3D printing. She, along with her team, was the first to execute soft tissue models in India through Paediatric Cardiology, partial amputee prosthetic hand, the first kidney tumor case in India, and the model for tongue cancer was the first in the world. Being a Co-founder and CTO of Anatomiz3D, she, along with her team, has successfully added 2000 plus case studies. Her multi-disciplinary expertise prevails in converting 2D DICOM CT/MRI/Echo Scans to 3D Printed anatomical replicas, medical devices, and allied products, using various combinations of Hardware and Software, across multiple medical specializations. Anatomiz3D has played a vital role in creating the market for 3D Printing in the Medical industry in India since 2015 and is a pioneer for the same, also being the first in India to enable Hospital-Industry partnerships for Point-of-Care Labs.

3D Bioprinting Cancer

Cancer, what a modern-day existential threat to humanity, is a word that triggers a cringe from the most fearless. Over the past decades in modern medicine, we have made much progress in cancer care, ranging from diagnosis, surgical advancements, to therapeutics. Despite that, cancer is surpassing heart diseases as a leading cause of death in the United States in 2020. [Ref] The demand for faster diagnostics and better treatment is driving researchers to technologies like 3D printing and 3D bioprinting. 

Speakers:

Dr. Antti Arjonen

Cancer research, microscopy, cell biology, image-based high-throughput screening, 3D bioprinting

Dr. Karolina Valente

Karolina has a B.Sc. and M.Sc. in Chemical Engineering, and a Ph.D. in Mechanical Engineering. She has deep expertise in tissue engineering, 3D bioprinting, and oncology. Karolina has published multiple peer-reviewed papers and is currently an Assistant Teaching Professor at the University of Victoria and the CEO & CSO of VoxCell BioInnovation.

Raphael Lichtnecker

I got my Master´s degree in Pharmaceutical Bioprocess Engineering at Technical University Munich. Afterwards I started as Business Development Manager at ViscoTec where I am responsible for the technology transfer of the progressive cavity pump to the bioprinting sector. I´m in this position for four years now.

Moderator:

Dr. Jenny Chen

jenny chen

Dr. Jenny Chen is trained as a neuroradiologist, founder/CEO of 3DHEALS. Her main interests include next generation education, 3D printing in the healthcare sector, automated biology, artificial intelligence. She is an angel investor who invests in Pitch3D companies.

Bioprinting Vasculatures

3D bioprinting vasculatures is perhaps the holy grail of the next industrial revolution in healthcare. Biofabrication and bioprinting of any viable three-dimensional tissue will not be successful unless the vascularization challenge has been solved. Many organizations and talents around the world are actively tackling this challenge, but where are we exactly? Hear the latest perspectives, updates, and revelations from a group of technical and industrial superstars. 

Speakers:

Taci Pereira

Taci Pereira is Vice President and General Manager, Bioprinting at 3D Systems, where she leads the development and commercialization of research tools for 3D bioprinting applications. Taci was previously the Chief Scientific Officer at Allevi, a startup 3D Systems acquired in 2021. Taci leads the 3D bioprinting working group for the Regenerative Medicine Manufacturing Society, a professional society dedicated to advancing manufacturing solutions for the field of regenerative medicine. Originally from Curitiba, Brazil , She holds a Bachelor of Science in Bioengineering from Harvard University, where she worked at the Wyss Institute for Biologically Inspired Engineering. Taci’s research at the Mooney Laboratory for Cell and Tissue Engineering (Wyss) focused on biomaterials for cancer immunotherapy, under the advisory of David Mooney, Ph.D.

Ibrahim T. Ozbolat

Ibrahim Tarik Ozbolat is an Associate Professor of Engineering Science and Mechanics, Biomedical Engineering and Neurosurgery, and a member of the Huck Institutes of the Life Sciences at Penn State University. Dr. Ozbolat’s main area of research is in the field of 3D Bioprinting. He has been working on several aspects of bioprinting such as bioprinting processes, bioink materials, bioprinters and post-bioprinting tissue maturation for manufacturing of more than a dozen tissues and organs. Dr. Ozbolat is a leading scientist with over 150 publications, including a sole-authored book in his domain. Due to his notable contributions to the field of bioprinting, he has received several prestigious international and national awards including 2014 NSF CAREER Award, 2014 SME Outstanding Young Manufacturing Engineer Award, 2014 ASME Chao and Trigger Young Manufacturing Engineer Award, 2014 ASME Tau Pi Sigma Gold Medal, 2015 IIE Dr. Hamid K. Eldin Outstanding Early Career Industrial Engineer in Academia Award, 2015 International Outstanding Young Researcher in Freeform and Additive Manufacturing Award and 2017 Hartz Family Career Development Professorship at Penn State.

Marc Thurner

Marc Thurner is a visionary, entrepreneur and pioneer in biofabrication technologies, currently acting as Chief Executive Officer at mimiX biotherapeutics Ltd. He pioneered the field of 3D bioprinting with his former creation regenHU Ltd, today recognized as an industry leader in the development of innovative biomedical solutions. A micro technology engineer Graduate, Marc started his professional career as an R&D engineer, managing international projects for the high precision automation industry. His avant-gardiste view that the future of regenerative medicine lay in converging engineering and biomedical science, brought him to found regenHU Ltd in 2007 and mimiX biotherapeutics Ltd in 2020. In 2012 Marc created the regenHU spin-off Vivos Dental Ltd, specialized in innovative 3D-printed bone grafting solutions for oral bone augmentation. Being an industry transformation leader, mimiX biotherapeutics develops leading-edge solutions in biotechnology and tissue engineering that enable scientific and clinical breakthroughs. The Swiss-based company collaborates with a global network of scientific innovators and industry players and leads the development of biomedical products for regenerative medicine and drug discovery. Marc Thurner and the mimiX biotherapeutics team are passionate about addressing the current and next generation biotechnology challenges to help the progress of Life Sciences.

Pierre-Alexandre LAURENT, PhD

During my PhD, I worked on the role of PI3Ks on the platelet functions and thrombus formation using in particular microfluidic/videomicroscopy technics. My postdoc research was focused on the development of 3D bone marrow models for the study of thrombocytopenia, developping bioreactor for ex-vivo platelet production and drug testing purposes using silk fibroin biomaterial and 3D bioprinting approach. I am now Senior Field Application Scientist at CELLINK, a BICO company promoting how our amazing bioconvergence technologies contribute to the future of biomedical research.

Moderator:

William Harley

William is a Ph.D. candidate within the School of Biomedical Engineering at the University of Melbourne. He obtained a certificate 3 in business management and an honors degree in medical biotechnology from the University of New South Wales where he first entered research focusing on biomaterials, stem cells, and nanofabrication processes for tissue regeneration. Currently, his Ph.D. investigates the use of acoustic micromanipulation and 3D bioprinting as tools to pattern and define the cellular microenvironment. William has held roles as a research assistant and a business development consultant, where he currently serves as a community and events manager for 3D Heals and an organizing committee member for the Australian Bioprinting Workshop.

3D Microfabrication: Medical Applications

What is microfabrication? Based on the latest definition, microfabrication is “a collection of technologies which are utilized in making microdevices.” As the name implies, 3D microfabrication is the manufacturing technique using layering of materials to produce a 3D structure at a typical scale of micrometer or even nanometer dimension. In other words, 3D printing at micro or nanometer scale. One commonly known 3D microfabrication or additive manufacturing microdevice process that can achieve this level of resolution includes 3D laser microfabrication such as laser direct-writing (LDW). Microfluidic devices are often produced using LDW. Microstereolithography, another common technique based on stereolithography principles fabricates 3D components by repeatedly layering photopolymerizable resin and curing under an ultraviolet laser. Finally, multiphoton lithography (e.g. two photopolymerizations) is another recognized 3D microfabrication process that can 3D printing sub-micrometer resolution). Over the past several years, there is an increasing interest in the space with a handful of new startups more visible in the spotlight in the 3D printing space. One of the driving forces is the enormous need to mass manufacture complex but small (if not smaller) medical devices. Examples include stents, microneedles, endoscopic components, and many others that are facing size challenges. Another driving force is the potential point of care of these devices meeting the design and manufacturing demand without facing external competition, trade secret loss, and supply chain crisis.

Speakers:

John Kawola

CEO of Boston Micro Fabrication

John is the CEO of Boston Micro Fabrication (BMF) an additive manufacturing technology company with a focus on high resolution, accuracy, and precision. From 2016 to 2019, John served as President-Americas for Ultimaker, the leading open-source desktop 3D printing company. From 2012 to 2016, John was the CEO of Harvest Automation. Harvest developed and deployed an autonomous mobile robotic platform that assists workers with difficult, repetitive material handling. John was VP of Sales and then CEO of Z Corporation from 1997 until 2012. Z Corporation led the way in introducing fast, easy to use and full-color 3D printing into a wide range of industries. John is also currently the Chairman of Labminds, a laboratory automation technology company, and a Board Director at Industrial ML, an industrial machine learning company. John received a BS in Mechanical Engineering from Cornell University, MS in Mechanical Engineering from Rensselaer, and an MBA from Union College.

Adam Steege

Adam Steege

After completing undergraduate work in Math, Physics, and Mechanical Engineering, Adam started his first company, Agile EndoSurgery. Agile developed novel articulated laparoscopic surgical devices, using a wide variety of fabrication techniques. Through this development process, as well as through his consulting work that resulted in the development of 3 other commercialized medical devices, Adam learned the potential and the shortcomings of 3d printing in medtech. With over 80 pending and issued patents, and 10 years of medical device development in addition to automation, robotics, and manufacturing expertise, Adam founded Trio Labs to solve the problems of precision and scalability in metal additive manufacturing.

Martin Hermatschweiler

Martin is CEO of Nanoscribe, the pioneer and market leader in high-precision additive manufacturing. Various, application-specific products underpin the expertise for specialized manufacturing scenarios such as prototyping, mastering, alignment with nanoprecision, and bioprinting. Nanoscribe is a spin-off of the Karlsruhe Institute of Technology (KIT) and belongs to the BICO Group since June 2021. With Nanoscribe, the BICO Group is the world’s first life science company with internal Two-Photon Polymerization (2PP) additive manufacturing capabilities. Martin is co-founder and managing partner of Nanoscribe, ever since the company was founded in 2007. The scientific expertise of the graduate physicist lies in laser patterning of polymers as well as in their casting into high refractive index optical materials. In 2015, he has been listed among the TOP 40 entrepreneurs within Germany younger than 40 years by the journal “Capital”, the so-called “young elite”.

Albert Folch

Albert Folch’s lab works at the interface between 3D-printing, microfluidics and cancer. He received both his BSc (1989) and PhD (1994) in Physics from the University of Barcelona (UB), Spain, in 1989. During his Ph.D. he was a visiting scientist from 1990–91 at the Lawrence Berkeley Lab working on AFM under Dr. Miquel Salmeron. From 1994–1996, he was a postdoc at MIT developing MEMS under Martin Schmidt (EECS) and Mark Wrighton (Chemistry). In 1997, he joined Mehmet Toner’s lab as a postdoc at Harvard-MGH to apply soft lithography to tissue engineering. He has been at Seattle’s UW BioE since June 2000, where he is now a full Professor, accumulating over 11,000 citations. In 20 years, he has supervised 18 postdocs (17% of whom have reached faculty rank), 12 Ph.D. students (25% faculty rank), 15 M.S. students, and >40 undergraduates. In 2001 he received an NSF Career Award, in 2006 a NASA Space Act Award, and in 2014 he was elected to the AIMBE College of Fellows (Class of 2015). He has served on the Advisory Board of Lab on a Chip between 2006-2017 and on the Editorial Board of Micromachines since 2019. He is the sole author of 5 books, including “Introduction to BioMEMS” (2012, Taylor&Francis), a textbook adopted by ~100 departments in 18 countries, and “Hidden in Plain Sight: The History, Science, and Engineering of Microfluidic Technology” (MIT Press, to appear in April 2022). Since 2007, the lab runs a celebrated outreach art program called BAIT (Bringing Art Into Technology), which has produced seven exhibits, a popular resource gallery of >2,000 free images related to microfluidics and microfabrication, and a YouTube channel that plays microfluidic videos with music which accumulates ~157,000 visits since 2009.

Abstract: 

The miniaturization of biomedical assays is of paramount importance for expanding healthcare access, for reducing healthcare costs, and for expediting biological research. However, biologists and clinicians typically do not have access to microfluidic technology because they do not have the engineering expertise or equipment required to fabricate and/or operate microfluidic devices. Furthermore, the present commercialization path for microfluidic devices is usually restricted to high-volume applications in order to recover the large investment needed to develop the plastic molding processes. We are developing microfluidic devices through stereolithography, a high-resolution form of 3D printing, in order to make microfluidic technology readily available via the web to biomedical scientists. Most available SL resins do not have all the favorable physicochemical properties of the above-named plastics (e.g., biocompatibility, transparency, elasticity, and gas permeability), so the performance of SL-printed devices is still inferior to that of equivalent PDMS devices. Inspired by the success of hydrogel PEG-DA biocompatibility, we have developed microfluidic devices by SL in resins that share all the advantageous attributes of PDMS and thermoplastics so that we can 3D-print designs with comparable performance and biocompatibility to those that are presently molded.

Moderator:

Dr. Jenny Chen

jenny chen

Dr. Jenny Chen is trained as a neuroradiologist, founder/CEO of 3DHEALS. Her main interests include next generation education, 3D printing in the healthcare sector, automated biology, artificial intelligence. She is an angel investor who invests in Pitch3D companies.

3D Bioprinting and Organoids

From 3D cell cultures, organoids, spheroids, to 3D bioprinted organoids, a lot of these concepts aren’t exactly explained accurately in the popular media, despite the fact that 3D tissue cultures are more than a decade old. In a recent Nature article, an organoid was defined as “a 3D multicellular in vitro tissue construct (using stem cells) that
mimics its corresponding in vivo organ, such that it can be used to study aspects of that organ in the tissue culture dish.” However, such a construct is not without problems. Challenges of reproducibility, lack of complexity, and lack of vasculatures and immune cells are preventing this method to be fully and widely adopted to the applications organoids promised to accomplish. 3D printing or the 3D bioprinting method appears to offer solutions in the next generation of organoids and 3D tissue culture.

Speakers:

Stephanie Willerth

Dr. Willerth, a Full Professor in Biomedical Engineering, holds a Canada Research Chair in Biomedical Engineering at the University of Victoria where she has dual appointments in the Department of Mechanical Engineering and the Division of Medical Sciences. She also holds an appointment with the School of Biomedical Engineering at the University of British Columbia. She recently founded the start-up company – Axolotl Biosciences that sells high quality bioinks for bioprinting human tissue models. She is an active member of the steering committee of the B.C. Regenerative Medicine Initiative and the Stem Cell Network. She also serves as a staff scientist at Creative Destruction Lab. She served as the Acting Director of the Centre for Biomedical Research and the Biomedical Engineering undergraduate program at the University of Victoria from 2018-2021 and as the President of Canadian Biomaterials Society from 2018-2019.

Tania Hübscher

Tania Hübscher is a PhD student in the Laboratory of Stem Cell Bioengineering, at the Swiss Federal Institute of Technology (EPFL). She holds a Bachelor in Biology from the University of Neuchatel and a Master in Life Sciences from EPFL. She conducted her Master thesis at Stanford University. During that time, she became fascinated by stem cells and their potential and decided to pursue this research as a PhD. In Prof. Lutolf lab, we are mostly working with organoids, and bioengineering approaches towards the next generation of organoid cultures.

Y. Shrike Zhang

Dr. Zhang’s research interests include 3D bioprinting, organ-on-a-chip, biomaterials, regenerative engineering, and bioanalysis. He is an author of >265 peer-reviewed publications with citations of ~20,000 and h-index of 70. His scientific contributions have been recognized by over 40 regional, national and international awards.

Dr. Jenny Chen

jenny chen

Dr. Jenny Chen is trained as a neuroradiologist, founder/CEO of 3DHEALS. Her main interests include next generation education, 3D printing in the healthcare sector, automated biology, artificial intelligence. She is an angel investor who invests in Pitch3D companies.