The Lattice #50: June 29th, 2020

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The Lattice is 3DHEALS weekly recap of the latest developments, expert insights, academic publications, upcoming events in the world of healthcare 3D printing and biofabrication.  Have a cool 3D printed Lattice photo to share with us? Share @3dheals on Instagram or Twitter

About the Lattice this week: #Voronoi Lattice in nature, dragonfly wings, soap bubbles, and more, a collection of beautiful images of such occurrences from @i_archstudio on Instagram.

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Email: Rance Tino (tino.rance@gmail.com) if you want to pen an Expert Corner blog for us or want to share relevant news with us.

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Related Articles:

The Yellow Brick Road of 3D Bioprinting

3D Bioprinting Substrate Stiffness – Often Overlooked, But Always at Work

3D Bioprinting in Space?

Printing the Future: An Introduction to Additive Manufacturing in Space

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Germany’s Henkel joins Facebook advertising boycott June 30th, 2020

The Wistar Institute & Allevi Inc. Collaborate on 3D Bioprinting Project to Advance COVID-19 Research June 25, 2020

Synopsys, Samsung Team Up to Roll Out Cloud Design Platform June 19th, 2020

CELLINK CELLINK has been granted a patent for “3D bioprinter and a 3D bioprinter system” from The Swedish Patent and Registration Office June 24th, 2020

This 3D printed ‘bone brick’ could transform how we treat bomb injuries – inside story June 18th, 2020  

Curtin research into 3D printing of skin awarded medical funding June 22nd, 2020 

ROKIT Healthcare Reveals World’s First All-in-One Bioprinting Platform with Built-in Bioreactor Chamber, Plasma Sterilizer and 6 Rotary Printheads: Dr. INVIVO 4D6 June 25th, 2020  

3D Printing for Preoperative Simulation of Complex Cardiovascular Surgery June 27th, 2020  

MT Ortho Advances in Production of 3D-Printed Prostheses for Cranioplasty & Bone Cancer Patients June 27th, 2020  

3D Systems Figure 4 gets pair of new 3D Printing materials June, 5th, 2020

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3D printed deformable sensors – Authored by Zhijie Zhu, Soo, Michael C. McAlpine. Science Advances, 17 June 2020

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Schematic images of (A) 3D scanning of the lung surface, (B) real-time tracking of the breathing lung, (C) adaptive printing of the hydrogel ink on the breathing lung, and (D) in situ monitoring of lung deformation with the EIT sensor. Copyright.  Science Advances 

Abstract: 

The ability to directly print compliant biomedical devices on live human organs could benefit patient monitoring and wound treatment, which requires the 3D printer to adapt to the various deformations of the biological surface. We developed an in situ 3D printing system that estimates the motion and deformation of the target surface to adapt the toolpath in real time. With this printing system, a hydrogel-based sensor was printed on a porcine lung under respiration-induced deformation. The sensor was compliant to the tissue surface and provided continuous spatial mapping of deformation via electrical impedance tomography. This adaptive 3D printing approach may enhance robot-assisted medical treatments with additive manufacturing capabilities, enabling autonomous and direct printing of wearable electronics and biological materials on and inside the human body.

3D-printed bioreactors for DNA amplification: application to companion diagnostics – Authored by A.K.Pantazis, G.Papadakis, K.Parasyris, A.Stavrinidis, E.Gizeli. Sensors and Actuators B: Chemical, 15 September 2020

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Photos of 3D printed vials and corresponding materials. Copyright. Sensors and Actuators B: Chemical

Abstract: 

The aim of this work is to employ 3D printing for the fabrication of bioreactors for DNA amplification with the long term aim to use them to healthcare applications. Initially, the most suitable printing material for the amplification reactor was evaluated by testing 25 different commercially available filaments, 3D-printed through the fused filament fabrication (FFF) method. Evaluation was carried out against materials printing efficiency, compatibility with the enzymatic DNA amplification assay and transparency. The best-performing transparent material was further used for the fabrication of a cartridge with eight micro-well reactors; the latter was demonstrated to be able to perform LAMP isothermal amplification in saliva samples when placed inside a purpose-made 3D printed portable platform. The successful detection of the CYP2C19*2 mutation involved in the metabolism of clopidogrel (Plavix), a drug used as a treatment to cardiovascular diseases, demonstrates the suitability of the platform as a companion diagnostic tool, emphasizing the potential of the method as a point-of-care system.

Performance of 3D printed plastic scintillators for gamma-ray detection – Authored by Dong-geon Kim, Sangmin Lee, Junesic Park, Jaebum Son, Tae Hoon Kim, Yong Hyun Kim, Kihong Pak, Yong Kyun Kim. Nuclear Engineering and Technology, 6 June 2020. 

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The printed scintillators when in standard conditions (A) and when irradiated (B). Photos via Hanyang University. 

Abstract: 

Digital light processing three-dimensional (3D) printing technique is a powerful tool to rapidly manufacture plastic scintillators of almost any shape or geometric features. In our previous study, the main properties of light output and transmission were analyzed. However, a more detailed study of the other properties is required to develop 3D printed plastic scintillators with expectable and reproducible properties. The 3D printed plastic scintillator displayed an average decay time constants of 15.6 ns, intrinsic energy resolution of 13.2%, and intrinsic detection efficiency of 6.81% for 477 keV Compton electrons from the 137Cs γ-ray source. The 3D printed plastic scintillator showed a similar decay time and intrinsic detection efficiency as that of a commercial plastic scintillator BC408. Furthermore, the presented estimates for the properties showed good agreement with the analyzed data.

3D Printing in Suspension Baths: Keeping the Promises of Bioprinting Afloat – Authored by Andrew McCormack, Christopher B.Highley, Nicholas R.Leslie, Ferry P.W. Melchels. Trends in Biotechnology, 1 June 2020. 

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Schematic Representation of the 3D Bioprinting in a Suspension Medium Strategy.(A) Writing of bioink material in a self-healing suspension, (B) Computer-aided design of intricate, non–self-supporting arterial tree, (C) Example of a printed arterial tree that has been printed in a gelatin slurry suspension. Copyright. Trends in Biotechnology

Abstract: 

Extrusion-based 3D printers have been adopted in pursuit of engineering functional tissues through 3D bioprinting. However, we are still a long way from the promise of fabricating constructs approaching the complexity and function of native tissues. A major challenge is presented by the competing requirements of biomimicry and manufacturability. This opinion article discusses 3D printing in suspension baths as a novel strategy capable of disrupting the current bioprinting landscape. Suspension baths provide a semisolid medium to print into, voiding many of the inherent flaws of printing onto a flat surface in air. We review the state-of-the-art of this approach and extrapolate toward future possibilities that this technology might bring, including the fabrication of vascularized tissue constructs.

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[COVID-19 Supply 3D models] NIH 3D print Exchange Updated June 27th, 2020  

From Corvette To COVID-19 Response: How 3D Printing Transforms Technology for General Motors June 18th, 2020  

Essentium supplies over 60K 3D printed face masks to State of Texas June 24th, 2020  

3D printing to thrive during COVID-19 and beyond June 24th, 2020   

University of Buffalo students use 3D printing to make face shields for local dentists June 26th, 2020  

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