The Lattice #48: June 15th, 2020

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The Lattice is 3DHEALS weekly recap of the latest developments, expert insights, academic publications, upcoming events in the world of healthcare 3D printing and biofabrication.  Have a cool 3D printed Lattice photo to share with us? Share @3dheals on Instagram or Twitter

About the Lattice this week: From our Instagram feed this past week. This is called “Increase Trees” by @canvas.51, using #generativedesign RT @canvas.51 

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Email: Rance Tino (tino.rance@gmail.com) if you want to pen an Expert Corner blog for us or want to share relevant news with us.

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Related Articles:

An Introduction to Scaffolds for Tissue Engineering of the Bone and Cartilage

3D Bioprinting Bone – One Defect At A Time

Patent Protection for Medical 3D Printing & Bioprinting Technologies

Control your 3D Bioprinting Hydrogels

Bio Fabrication Techniques for Bone and Cartilage Tissue Regeneration

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Just published! A fun but insightful conversation during 3DHEALS2020 with two inspiring entrepreneurs in 3D Bioprinting space, Tamer Mohamed (CEO and co-founder of Aspect Biosystems), and Mike Graffeo (CEO and co-founder of Fluidform). Aspect bio has just successfully completed its series A round, and Fluidform just successfully raised its seed round. Learn from Tamer and Mike on what startup CEOs’ challenges, experiences, visions, and advice for the biofabrication and 3D printing space.

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3DHEALS2020 Full Recording Now Online

Here is one of the keynote video from Dr. Alan Dang (UCSF, PrinterPrezz)

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Process from scan to finished print. [Recorded Webinar] May 14th, 2020 (Part of a webinar series)

Automating Surface Finishing and Powder Removal for Dental Applications June 3rd, 2020

18-12 months-Outdated in India Receives 3D-Printed Shinbone Implant June 5th, 2020

3DHEALS 2020 Virtual Medical Summit: Comprehensive Look at Craniomaxillofacial 3D Printing June 9th, 2020

Fast Radius and Axial3D Announce Partnership to Transform 3D Modeling for Surgical Planning June 9th, 2020

Lab makes 4D printing more practical June 9th, 2020

Lonza And Cellink Join Forces To Offer Complete 3D Cell Culture Workflows June 10th, 2020

Collaborative Research to Develop Custom, 3D-Printed Nitinol Stents for Children June 11th, 2020

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Noninvasive in vivo 3D bioprinting – Authored by Yuwen Chen, Jiumeng Zhang, Xuan Liu, Shuai Wang, Jie Tao, Yulan Huang, Wenbi Wu, Yang Li, Kai Zhou, Xiawei Wei, Shaochen Chen, Xiang Li, Xuewen Xu, Ludwig Cardon, Zhiyong Qian and Maling Gou. Science Advances, 3 June 2020

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Non-invasive 3D bioprinting conformal ASC-laden scaffold for muscle defect repair by the DNP-based process. (A) Schematic illustration of the conformal ASC-laden scaffold for muscle defect repair. (B) Representative images exhibit acceleration of the wound healing of the DNP group compared with control. Scale bar, 5 mm. (C) Percent closure of muscle wounds evaluated at day 10. **P < 0.01, n = 5. (D) H&E histological analysis of muscle wound healing at day 10 after treatments. Scale bar, 50 μm. Photo credit: Yuwen Chen, State Key Laboratory of Biotherapy and Cancer Center. 

Abstract: 

Three-dimensional (3D) printing technology has great potential in advancing clinical medicine. Currently, the in vivo application strategies for 3D-printed macroscale products are limited to surgical implantation or in situ 3D printing at the exposed trauma, both requiring exposure of the application site. Here, we show a digital near-infrared (NIR) photopolymerization (DNP)–based 3D printing technology that enables the noninvasive in vivo 3D bioprinting of tissue constructs. In this technology, the NIR is modulated into customized pattern by a digital micromirror device, and dynamically projected for spatially inducing the polymerization of monomer solutions. By ex vivo irradiation with the patterned NIR, the subcutaneously injected bioink can be noninvasively printed into customized tissue constructs in situ. Without surgery implantation, a personalized ear-like tissue constructs with chondrification and a muscle tissue repairable cell-laden conformal scaffold were obtained in vivo. This work provides a proof of concept of noninvasive in vivo 3D bioprinting.

Recent Advances in Enabling Technologies in 3D Printing for Precision Medicine – Authored by Margaret E. Prendergast, Jason A. Burdick. Advanced Materials, 12 September 2019

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3D printing for precision medicine. The 3D printing process can be split into modular steps for a unit‐based systems approach for precision medicine.The first step, A) design, involves analysis of patient‐specific medical data such as genetics, imaging, and history. This informs the second step, B) select, where biomaterial/bioinks and bioactive components such as cells, growth factors, and drugs are selected for the therapy. These components may be mixed together or introduced separately for the next step, C) print. After printing, constructs may be D) cultured in vitro, E) directly implanted for applications such as personalized implants or precision delivery of therapeutics or cultured in vitro and then implanted. F) screen. Further, screening may inform designs and decisions for implantation of precision therapeutics. Copyright. Advanced Materials

Abstract: 

Advances in areas such as data analytics, genomics, and imaging have revealed individual patient complexities and exposed the inherent limitations of generic therapies for patient treatment. These observations have also fueled the development of precision medicine approaches, where therapies are tailored for the individual rather than the broad patient population. 3D printing is a field that intersects with precision medicine through the design of precision implants with patient‐directed shapes, structures, and materials or for the development of patient‐specific in vitro models that can be used for screening precision therapeutics. Toward their success, advances in 3D printing and biofabrication technologies are needed with enhanced resolution, complexity, reproducibility, and speed and that encompass a broad range of cells and materials. The overall goal of this progress report is to highlight recent advances in 3D printing technologies that are helping to enable advances important in precision medicine.

Can an entry-level 3D printer create high-quality anatomical models? Accuracy assessment of mandibular models printed by a desktop 3D printer and a professional device – Authored by C.R.Hatz. B. Msallem, S. Aghlmandi, P. Brantner, F.M. Thieringer. International Journal of Oral and Maxillofacial Surgery, 1 January 2020. 

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Heat map of the model comparison. Left: Comparison FFF01 to SLS01. Right: Comparison FFF10 to SLS10. FFF, fused filament fabrication (desktop 3D printer); SLS, selective laser sintering (professional-grade 3D printer). Copyright. International Journal of Oral and Maxillofacial Surgery

Abstract: 

This study was performed to determine whether an in-house printed mandible model is sufficiently accurate for daily clinical practice. Ten example mandible models were produced with a desktop 3D printer (fused filament fabrication, FFF) and compared with 10 equivalent mandible models fabricated using a professional-grade 3D printer (selective laser sintering, SLS). To determine the precision of the printed models, each model was scanned with an optical scanner. Subsequently, every model was compared to its original standard tessellation language (STL) file and to its corresponding analogue. Mean ± standard deviation and median (interquartile range) differences were calculated. Overall these were −0.019 ± 0.219 mm and −0.007 (−0.129 to 0.107) mm for all 10 pairs. Furthermore, correlation of all printed models to their original STL files showed a high level of accuracy. Comparison of the SLS models with their STL files revealed a mean difference of −0.036 ± 0.114 mm and median difference of −0.028 (−0.093 to 0.030) mm. Comparison of the FFF models with their STL files yielded a mean difference of −0.055 ± 0.227 mm and median difference of −0.022 (−0.153 to 0.065) mm. The study findings confirm that in-house 3D printed mandible models are economically favourable as well as suitable substitutes for professional-grade models, in particular considering the geometric aspects.

Creating patient-specific anatomical models for 3D printing and AR/VR: a supplement for the 2018 Radiological Society of North America (RSNA) hands-on course – Authored by Nicole Wake, Amy E. Alexander, Andy M. Christensen, Peter C. Liacouras, Maureen Schickel, Todd Pietila & Jane Matsumoto. 3D Printing in Medicine Journal, 30 December 2019

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a Coronal CT image showing thresholded right pelvic bones, showing similar colors for the pubis, ischium, and femur. b Coronal CT image showing splitting of the pelvis (blue) from the femur (black). c 3D computer model showing the pubis (white) and ischium (yellow). d Photograph of 3D printed model. Copyright. 3D Printing in Medicine

Abstract:

Advanced visualization of medical image data in the form of three-dimensional (3D) printing continues to expand in clinical settings and many hospitals have started to adapt 3D technologies to aid in patient care. It is imperative that radiologists and other medical professionals understand the multi-step process of converting medical imaging data to digital files. To educate health care professionals about the steps required to prepare DICOM data for 3D printing anatomical models, hands-on courses have been delivered at the Radiological Society of North America (RSNA) annual meeting since 2014. In this paper, a supplement to the RSNA 2018 hands-on 3D printing course, we review methods to create cranio-maxillofacial (CMF), orthopedic, and renal cancer models which can be 3D printed or visualized in augmented reality (AR) or virtual reality (VR).

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[NIH 3D print Exchange: 3D model database] COVID-19 Supply Chain Response Updated June 11th, 2020

3D Printed Medical Manikins Become Effective Training Aids for Respiratory Swab Collection June 9th, 2020

Seattle hospital bus drivers receive 3D printed protection for COVID-19 June 10th, 2020

Formnext 2020 reveals part of COVID-19 strategy for November June 10th. 2020

3DHEALS Weekly Newsletter (The Lattice) Archive

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